Trial reportDepression and anxiety2012
Long-term efficacy of repeated daily prefrontal transcranial magnetic stimulation (TMS) in treatment-resistant depression.
Trial report in Depression and anxiety, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04210557 (Models of Auditory Hallucination), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Models of Auditory Hallucination
Who cites it
21 citing papers in PubMed, 58 citations in OpenAlex.
- A naturalistic study comparing the efficacy of unilateral and bilateral sequential theta burst stimulation in treating major depression - the U-B-D study protocol.BMC psychiatry · 2023Article
- Effectiveness of antidepressant repetitive transcranial magnetic stimulation in a patient with refractory psychogenic dysphagia: A case report and review of literature.World journal of clinical cases · 2023Article
- Training augmentation using additive sensory noise in a lunar rover navigation task.Frontiers in neuroscience · 2023Article
- Efficiently identifying individuals at high risk for treatment resistance in major depressive disorder using electronic health records.Journal of affective disorders · 2022Article
- Motor Imagery: How to Assess, Improve Its Performance, and Apply It for Psychosis Diagnostics.Diagnostics (Basel, Switzerland) · 2022Review
- "The Heart Asks Pleasure First"-Conceptualizing Psychiatric Diseases asBrain sciences · 2022Article
- rTMS Reduces Craving and Alcohol Use in Patients with Alcohol Use Disorder: Results of a Randomized, Sham-Controlled Clinical Trial.Journal of clinical medicine · 2022Article
- The Care of Patients With Complex Mood Disorders.Focus (American Psychiatric Publishing) · 2020Article
- Antidepressant efficacy and side effect burden: an updated guide for clinicians.Drugs in context · 2020Review
- Review
- SSRI and Motor Recovery in Stroke: Reestablishment of Inhibitory Neural Network Tonus.Frontiers in neuroscience · 2017Article
- Use of the Temperament and Character Inventory to Predict Response to Repetitive Transcranial Magnetic Stimulation for Major Depression.Journal of psychiatric practice · 2016Article
- Bibliography: Depression: Challenges and Treatments.Focus (American Psychiatric Publishing) · 2016Article
- Transcranial magnetic stimulation for the treatment of major depression.Neuropsychiatric disease and treatment · 2015Review
- Transcranial magnetic stimulation in the treatment of substance addiction.Annals of the New York Academy of Sciences · 2014Review
- Transcranial magnetic stimulation maintenance as a substitute for maintenance electroconvulsive therapy: a case series.The journal of ECT · 2013Article
- The expanding evidence base for rTMS treatment of depression.Current opinion in psychiatry · 2013Review
- Neuromodulation for treatment-resistant depression.F1000 medicine reports · 2012Article
- Safe management of a bipolar depressed patient with prefrontal repetitive transcranial magnetic stimulation (rTMS) Over 7 years and >2 million stimuli.Brain stimulationArticle
- The Clinical TMS Society Consensus Review and Treatment Recommendations for TMS Therapy for Major Depressive Disorder.Brain stimulationReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 9 institutions in 3 countries.
Funding
Abstract
backgroundA few studies have examined the durability of transcranial magnetic stimulation (TMS) antidepressant benefit once patients remitted. This study examined the long-term durability of clinical benefit from TMS using a protocol-specified TMS taper and either continuation pharmacotherapy or naturalistic follow-up.
methodsPatients were remitters from an acute double-blind sham-controlled trial of TMS (n = 18), or from an open-label extension in patients who did not respond to the acute trial (n = 43). Long-term durability of TMS acute effect was examined in remitters over a 12-week follow-up. Relapse, defined as 24-item Hamilton Depression Rating Scale (HDRS-24) ≥20, was the primary outcome.
resultsOf 61 remitters in the acute trial, five entered naturalistic follow-up and 50 entered the TMS taper. Thirty-two patients completed TMS taper and 1-, 2-, and 3-month follow-up. At 3-month visit, 29 of 50 (58%) were classified as in remission (HDRS-24 ≤10), two of 50 (4%) as partial responders (30%≤ HDRS-24 reduction <50% from baseline), and one of 50 (2%) met criteria for relapse. During the entire 3-month follow-up, five of the 37 patients relapsed (relapse rate = 13.5%), but four of them regained remission by the end of the study. The average time to relapse in these five patients was 7.2 ± 3.3 weeks. Patients who relapsed had higher depression scores at 1 month.
conclusionsWhile one third of the sample was lost to follow-up, our results demonstrate that most patients contributing to observations experienced persistence of benefit from TMS followed by pharmacotherapy or no medication. Longer follow-up and more rigorous studies are needed to explore the true long-term durability of remission produced by TMS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.