ReviewEndocrinology2012
Minireview: aldosterone biosynthesis: electrically gated for our protection.
Review in Endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Channelopathy linkingJCEM case reports · 2026Article
- Recent insights into sodium and potassium handling by the aldosterone-sensitive distal nephron: a review of the relevant physiology.Journal of nephrology · 2020Review
- Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes.Nature communications · 2020Article
- Na/K Pump Mutations Associated with Primary Hyperaldosteronism Cause Loss of Function.Biochemistry · 2019Article
- The Biology of Normal Zona Glomerulosa and Aldosterone-Producing Adenoma: Pathological Implications.Endocrine reviews · 2018Review
- Endogenous Purification of NR4A2 (Nurr1) Identified Poly(ADP-Ribose) Polymerase 1 as a Prime Coregulator in Human Adrenocortical H295R Cells.International journal of molecular sciences · 2018Article
- Mouse Models of Primary Aldosteronism: From Physiology to Pathophysiology.Endocrinology · 2017Article
- Functional TASK-3-Like Channels in Mitochondria of Aldosterone-Producing Zona Glomerulosa Cells.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Role of voltage-gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex.The Journal of physiology · 2016Review
- Small-Conductance Ca2+-Activated Potassium Channels Negatively Regulate Aldosterone Secretion in Human Adrenocortical Cells.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Potassium channels related to primary aldosteronism: Expression similarities and differences between human and rat adrenals.Molecular and cellular endocrinology · 2015Article
- The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential.Pharmacological reviews · 2015Review
- Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Physiological reviews · 2015Review
- A novel KCNJ5-insT149 somatic mutation close to, but outside, the selectivity filter causes resistant hypertension by loss of selectivity for potassium.The Journal of clinical endocrinology and metabolism · 2014Article
- Channels and pumps in aldosterone-producing adenomas.The Journal of clinical endocrinology and metabolism · 2014Article
- Overview of the genetic determinants of primary aldosteronism.The application of clinical genetics · 2014Review
- Minireview: potassium channels and aldosterone dysregulation: is primary aldosteronism a potassium channelopathy?Endocrinology · 2014Review
- Regulation of aldosterone biosynthesis by the Kir3.4 (KCNJ5) potassium channel.Clinical and experimental pharmacology & physiology · 2013Review
- Regulation of adrenocortical steroid hormone production by RhoA-diaphanous 1 signaling and the cytoskeleton.Molecular and cellular endocrinology · 2013Review
- Lessons from the gene expression pattern of the rat zona glomerulosa.Molecular and cellular endocrinology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Aldosterone produced by adrenal zona glomerulosa (ZG) cells plays an important role in maintaining salt/water balance and, hence, blood pressure homeostasis. However, when dysregulated, aldosterone advances renal and cardiovascular disease states. Multiple steps in the steroidogenic pathway require Ca(2+), and the sustained production of aldosterone depends on maintained Ca(2+) entry into the ZG cell. Nevertheless, the recorded membrane potential of isolated ZG cells is extremely hyperpolarized, allowing the opening of only a small fraction of low-voltage-activated Ca(2+) channels of the Ca(v)3.x family, the major Ca(2+) conductance on the ZG cell membrane. As a consequence, to activate sufficient Ca(2+) channels to sustain the production of aldosterone, aldosterone secretagogs would be required to affect large decreases in membrane voltage, a requirement that is inconsistent with the exquisite sensitivity of aldosterone production in vivo to small changes (0.1 mm) in extracellular K(+). In this review, we evaluate the contribution of membrane voltage and voltage-dependent Ca(2+) channels to the control of aldosterone production and consider data highlighting the electrical excitability of the ZG cell. This intrinsic capacity of ZG cells to behave as electrical oscillators provides a platform from which to generate a recurring Ca(2+) signal that is compatible with the lengthy time course of steroidogenesis and provides an alternative model for the physiological regulation of aldosterone production that permits both amplitude and temporal modulation of the Ca(2+) signal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.