ArticleThe American journal of gastroenterology2012
Colorectal endoscopy, advanced adenomas, and sessile serrated polyps: implications for proximal colon cancer.
Article in The American journal of gastroenterology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
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Who cites it
29 citing papers in PubMed, 55 citations in OpenAlex.
- Dysbiosis promotes recurrence of adenomatous polyps in the distal colorectum.World journal of gastrointestinal oncology · 2024Article
- Prevalence and predictive factors of colorectal sessile serrated lesions in younger individuals.Endoscopy · 2024Article
- Acceleration of benzo(a)pyrene-induced colon carcinogenesis by Western diet in a rat model of colon cancer.Current research in toxicology · 2024Article
- Colorectal cancer screening-what does the recent NordICC trial mean for the U.S. population?Translational gastroenterology and hepatology · 2023Review
- Review
- Advanced Colorectal Polyps on Colonoscopy: A Trigger for Earlier Screening of Family Members.The American journal of gastroenterology · 2020Article
- Serrated neoplasia pathway as an alternative route of colorectal cancer carcinogenesis.Intestinal research · 2018Review
- Article
- A Comprehensive Model of Colorectal Cancer by Risk Factor Status and Subsite Using Data From the Nurses' Health Study.American journal of epidemiology · 2017Article
- Validation of Models Used to Inform Colorectal Cancer Screening Guidelines: Accuracy and Implications.Medical decision making : an international journal of the Society for Medical Decision Making · 2016Article
- Multi-Target Stool DNA Test: Is the Future Here?Current gastroenterology reports · 2016Review
- Serrated polyps of the colon and rectum: Endoscopic features including image enhanced endoscopy.World journal of gastrointestinal endoscopy · 2015Review
- Multi-target stool DNA test: a new high bar for noninvasive screening.Digestive diseases and sciences · 2015Review
- A healthy lifestyle index is associated with reduced risk of colorectal adenomatous polyps among non-users of non-steroidal anti-inflammatory drugs.The journal of primary prevention · 2015Article
- Pathogenesis and management of serrated polyps: current status and future directions.Gut and liver · 2014Review
- Impact of fair bowel preparation quality on adenoma and serrated polyp detection: data from the New Hampshire colonoscopy registry by using a standardized preparation-quality rating.Gastrointestinal endoscopy · 2014Article
- Pathological features of the sessile serrated adenoma/polyp with special references of its carcinogenesis.Medical molecular morphology · 2014Review
- IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions.World journal of gastroenterology · 2014Article
- Variation in the association between colorectal cancer susceptibility loci and colorectal polyps by polyp type.American journal of epidemiology · 2014Article
- Serrated and adenomatous polyp detection increases with longer withdrawal time: results from the New Hampshire Colonoscopy Registry.The American journal of gastroenterology · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
objectivesColonoscopy is associated with a decreased risk of colorectal cancer but may be more effective in reducing the risk of distal than proximal malignancies. To gain insight into the differences between proximal and distal colon endoscopic performance, we conducted a case-control study of advanced adenomas, the primary targets of colorectal endoscopy screening, and sessile serrated polyps (SSPs), newly recognized precursor lesions for a colorectal cancer subset that occurs most often in the proximal colon.
methodsThe Group Health-based study population included 213 advanced adenoma cases, 172 SSP cases, and 1,704 controls aged 50-79 years, who received an index colonoscopy from 1998-2007. All participants completed a structured questionnaire covering endoscopy history. Participants with polyps underwent a standard pathology review to confirm the diagnosis and reclassify a subset as advanced adenomas or SSPs. Logistic regression analyses were conducted to estimate adjusted odds ratios (OR) and 95% confidence intervals (CI) for the association between endoscopy and advanced adenomas and SSPs separately; site-specific analyses were completed.
resultsPrevious endoscopy was inversely associated with advanced adenomas in both the rectum/distal colon (OR=0.38; 95% CI: 0.26-0.56) and proximal colon (OR=0.31; 95% CI: 0.19-0.52), but there was no statistically significant association between previous endoscopy and SSPs (OR=0.80; 95%CI: 0.56-1.13).
conclusionsOur results support the hypothesis that the effect of endoscopy differs between advanced adenomas and SSPs. This may have implications for proximal colon cancer prevention and be due to the failure of endoscopy to detect/remove SSPs, or the hypothesized rapid development of SSPs.
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Registered trials
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