Trial reportKidney & blood pressure research2012
Urate transporter gene SLC22A12 polymorphisms associated with obesity and metabolic syndrome in Caucasians with hypertension.
Trial report in Kidney & blood pressure research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Differential gene expression of ABCG2, SLC22A12, IL-1β, and ALPK1 in peripheral blood leukocytes of primary gout patients with hyperuricemia and their comorbidities: a case-control study.European journal of medical research · 2022Article
- TBXAS1 Gene Polymorphism Is Associated with the Risk of Ischemic Stroke of Metabolic Syndrome in a Chinese Han Population.Disease markers · 2022Article
- The impact of an URAT1 polymorphism on the losartan treatment of hypertension and hyperuricemia.Journal of clinical laboratory analysis · 2021Article
- Alterations in erythrocyte membrane transporter expression levels in type 2 diabetic patients.Scientific reports · 2021Observational
- Uric Acid and Hypertension: An Update With Recommendations.American journal of hypertension · 2020Review
- The association between genotypes of urate transporter-1, Serum uric acid, and mortality in the community-based population: the Yamagata (Takahata) Study.Clinical and experimental nephrology · 2019Article
- Temporal relationship between hyperuricemia and obesity, and its association with future risk of type 2 diabetes.International journal of obesity (2005) · 2018Article
- Hyperuricemia, Acute and Chronic Kidney Disease, Hypertension, and Cardiovascular Disease: Report of a Scientific Workshop Organized by the National Kidney Foundation.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2018Review
- Uric acid in the pathogenesis of metabolic, renal, and cardiovascular diseases: A review.Journal of advanced research · 2017Review
- Article
- Renal clearance of uric acid is linked to insulin resistance and lower excretion of sodium in gout patients.Rheumatology international · 2015Article
- Causal or Noncausal Relationship of Uric Acid With Diabetes.Diabetes · 2015Article
- A coronary artery disease-associated SNP rs6903956 contributed to asymptomatic hyperuricemia susceptibility in Han Chinese.Lipids in health and disease · 2015Article
- Uric acid and cardiac performance.Internal and emergency medicine · 2014Article
- Perinatal bisphenol A exposure promotes dose-dependent alterations of the mouse methylome.BMC genomics · 2014Article
- The role of drug transporters in the kidney: lessons from tenofovir.Frontiers in pharmacology · 2014Review
- Sugar, uric acid, and the etiology of diabetes and obesity.Diabetes · 2013Review
- The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality.BMC nephrology · 2013Review
- Redefining metabolic syndrome as a fat storage condition based on studies of comparative physiology.Obesity (Silver Spring, Md.) · 2013Review
- Genetics of hyperuricemia and gout: implications for the present and future.Current rheumatology reports · 2013Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
BACKGROUND/
aimsHyperuricemia is associated with obesity and the metabolic syndrome. URAT1 is a urate transporter, and we tested the association of URAT1 transporter gene (SLC22A12) polymorphisms with obesity and the metabolic syndrome in hypertensive subjects.
methodsPatients with essential hypertension (n = 414) from a randomized controlled study were genotyped for SLC22A12 SNPs rs11602903, rs505802 and rs11231825.
resultsIn Caucasians, SLC22A12 SNPs were associated with the body mass index (BMI). rs11602903 was associated with BMI (p < 0.0001), waist circumference (p = 0.003), HDL cholesterol (p = 0.018) and the metabolic syndrome (p = 0.033), and accounted for 7% of the variation of BMI in Caucasians. In African Americans, SLC22A12 SNP rs11602903 was not associated with BMI, waist circumference, HDL cholesterol or triglycerides.
conclusionThe URAT1 gene SLC22A12 polymorphism may play a role in obesity and the metabolic syndrome in Caucasian hypertensive subjects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.