ReviewMicrobiology and molecular biology reviews : MMBR2012
Biology of the heat shock response and protein chaperones: budding yeast (Saccharomyces cerevisiae) as a model system.
Review in Microbiology and molecular biology reviews : MMBR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 278 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
278 citing papers in PubMed, 587 citations in OpenAlex.
- Article
- Yeast species resource exploration and application in cell factories.Synthetic and systems biotechnology · 2026Review
- Stress-induced remodeling of yeast amino acid pools occurs within conserved physicochemical constraints.Folia microbiologica · 2026Article
- Metabolic Reprogramming During Heat Stress and Short-Term Recovery inJournal of fungi (Basel, Switzerland) · 2026Article
- Article
- Effect of Magnetic Field Treatment at Different Intensities on the Quality and Biological Properties of Bread Produced withACS omega · 2026Article
- Thermosensitivity of cellular translation restricts the growth of fission yeast at high temperatures.Communications biology · 2026Article
- Transcriptomic and Metabolomic Profiling of Heat Stress Responses and Ganoderic Acid Biosynthesis in Ganoderma lucidum.Applied biochemistry and biotechnology · 2026Article
- Development ofBiotechnology reports (Amsterdam, Netherlands) · 2026Article
- Placental Heat Shock Protein (HSP) Expression in Fetal Growth Restriction (FGR) Pregnancies: A Case-Control Immunohistochemistry Study.International journal of molecular sciences · 2026Article
- Dynamic sumoylation is essential in yeast for suppressing stress-induced gene expression in non-stress conditions.Nucleic acids research · 2026Article
- Engineering a robust cell-surface display platform in the multi-stress-tolerant yeast Issatchenkia orientalis.Applied microbiology and biotechnology · 2026Article
- Small heat shock proteins and biomolecular condensates.Cellular and molecular life sciences : CMLS · 2026Review
- Metacaspases contribute to the cellular response to heat stress in a marine diatom.The New phytologist · 2026Article
- ATP modulates holdase activity of fungal and human 110-kilodalton heat shock proteins to promote protein folding.Protein science : a publication of the Protein Society · 2026Article
- Mediator Tail Subunits Hierarchically Couple Transcriptional Condensates to Gene Activation and Genome Organization.bioRxiv : the preprint server for biology · 2026Article
- Integrating multiomic resources and gene expression studies to identify candidates for engineering climate-resilientFrontiers in plant science · 2026Review
- Research progress on heat stress response mechanisms inFrontiers in microbiology · 2026Review
- Effect of Heat Stress on the Biosynthesis of Exopolysaccharides fromJournal of fungi (Basel, Switzerland) · 2025Article
- Mechanosensor-mediated Hsp70 phosphorylation orchestrates the landscape of the heat shock response.Nature communications · 2025Article
218 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The eukaryotic heat shock response is an ancient and highly conserved transcriptional program that results in the immediate synthesis of a battery of cytoprotective genes in the presence of thermal and other environmental stresses. Many of these genes encode molecular chaperones, powerful protein remodelers with the capacity to shield, fold, or unfold substrates in a context-dependent manner. The budding yeast Saccharomyces cerevisiae continues to be an invaluable model for driving the discovery of regulatory features of this fundamental stress response. In addition, budding yeast has been an outstanding model system to elucidate the cell biology of protein chaperones and their organization into functional networks. In this review, we evaluate our understanding of the multifaceted response to heat shock. In addition, the chaperone complement of the cytosol is compared to those of mitochondria and the endoplasmic reticulum, organelles with their own unique protein homeostasis milieus. Finally, we examine recent advances in the understanding of the roles of protein chaperones and the heat shock response in pathogenic fungi, which is being accelerated by the wealth of information gained for budding yeast.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.