ArticleToxicologic pathology2012
Differential transcriptomic analysis of spontaneous lung tumors in B6C3F1 mice: comparison to human non-small cell lung cancer.
Article in Toxicologic pathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Procedural application of mode-of-action and human relevance analysis: styrene-induced lung tumors in mice.Critical reviews in toxicology · 2024Review
- Potent lung tumor promotion by inhaled MWCNT.Nanotoxicology · 2024Article
- Time-Course of Transcriptomic Change in the Lungs of F344 Rats Repeatedly Exposed to a Multiwalled Carbon Nanotube in a 2-Year Test.Nanomaterials (Basel, Switzerland) · 2023Article
- Single-Walled vs. Multi-Walled Carbon Nanotubes: Influence of Physico-Chemical Properties on Toxicogenomics Responses in Mouse Lungs.Nanomaterials (Basel, Switzerland) · 2023Article
- High complement protein C1q levels in pulmonary fibrosis and non-small cell lung cancer associated with poor prognosis.BMC cancer · 2022Article
- AnApplied in vitro toxicology · 2018Article
- Application of bi-clustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials.Data in brief · 2017Article
- Article
- A multiple testing procedure for multi-dimensional pairwise comparisons with application to gene expression studies.BMC bioinformatics · 2016Article
- Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice.Toxicologic pathology · 2015Article
- Mixed directional false discovery rate control in multiple pairwise comparisons using weighted p-values.Biometrical journal. Biometrische Zeitschrift · 2015Article
- Application of biclustering of gene expression data and gene set enrichment analysis methods to identify potentially disease causing nanomaterials.Beilstein journal of nanotechnology · 2015Article
- Comparative pathobiology of environmentally induced lung cancers in humans and rodents.Toxicologic pathology · 2015Review
- Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes.Particle and fibre toxicology · 2014Article
- A transcriptomic insight into the impacts of mast cells in lung, breast, and colon cancers.OncoimmunologyArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Lung cancer is the leading cause of cancer-related death in people and is mainly due to environmental factors such as smoking and radon. The National Toxicology Program (NTP) tests various chemicals and mixtures for their carcinogenic hazard potential. In the NTP chronic bioassay using B6C3F1 mice, the incidence of lung tumors in treated and control animals is second only to the liver tumors. In order to study the molecular mechanisms of chemically induced lung tumors, an understanding of the genetic changes that occur in spontaneous lung (SL) tumors from untreated control animals is needed. The authors have evaluated the differential transcriptomic changes within SL tumors compared to normal lungs from untreated age-matched animals. Within SL tumors, several canonical pathways associated with cancer (eukaryotic initiation factor 2 signaling, RhoA signaling, PTEN signaling, and mammalian target of rapamycin signaling), metabolism (Inositol phosphate metabolism, mitochondrial dysfunction, and purine and pyramidine metabolism), and immune responses (FcγR-mediated phagocytosis, clathrin-mediated endocytosis, interleukin 8 signaling, and CXCR4 signaling) were altered. Meta-analysis of murine SL tumors and human non-small cell lung cancer transcriptomic data sets revealed a high concordance. These data provide important information on the differential transcriptomic changes in murine SL tumors that will be critical to our understanding of chemically induced lung tumors and will aid in hazard analysis in the NTP 2-year carcinogenicity bioassays.
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Registered trials
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