Trial reportDiabetes2012
Fully integrated artificial pancreas in type 1 diabetes: modular closed-loop glucose control maintains near normoglycemia.
Trial report in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 135 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Hypoglycemia Prevention After Exercise in Adolescent T1DM Patients Using a Control to Range System
Feasibility Study of a Modular Control to Range System in T1DM
Setting a New Algorithm For the Management of Exercise-induced Glycemic Variations in Patients With Type 1 Diabetes in Intensive Therapy With Hybrid Closed-loop Systems
Who cites it
135 citing papers in PubMed, 1 synthesis or guideline pooled it, 308 citations in OpenAlex.
- Algorithms for a closed-loop artificial pancreas: the case for proportional-integral-derivative control.Journal of diabetes science and technology · 2013Pooled it
- Glycemic outcomes of children 2-6 years of age with type 1 diabetes during the pediatric MiniMed™ 670G system trial.Pediatric diabetes · 2022Trial
- Manual Closed-Loop Insulin Delivery Using a Saddle Point Model Predictive Control Algorithm: Results of a Crossover Randomized Overnight Study.Journal of diabetes science and technology · 2017Trial
- Psychosocial Impact of the Bionic Pancreas During Summer Camp.Journal of diabetes science and technology · 2016Trial
- Day-and-Night Hybrid Closed-Loop Insulin Delivery in Adolescents With Type 1 Diabetes: A Free-Living, Randomized Clinical Trial.Diabetes care · 2016Trial
- Home Use of an Artificial Beta Cell in Type 1 Diabetes.The New England journal of medicine · 2015Trial
- Metabolic Control With the Bio-inspired Artificial Pancreas in Adults With Type 1 Diabetes: A 24-Hour Randomized Controlled Crossover Study.Journal of diabetes science and technology · 2015Trial
- Sensitivity of the Predictive Hypoglycemia Minimizer System to the Algorithm Aggressiveness Factor.Journal of diabetes science and technology · 2015Trial
- Unsupervised home use of an overnight closed-loop system over 3-4 weeks: a pooled analysis of randomized controlled studies in adults and adolescents with type 1 diabetes.Diabetes, obesity & metabolism · 2015Trial
- Multinight "bedside" closed-loop control for patients with type 1 diabetes.Diabetes technology & therapeutics · 2015Trial
- Preliminary evaluation of a new semi-closed-loop insulin therapy system over the prandial period in adult patients with type 1 diabetes: the WP6.0 Diabeloop study.Journal of diabetes science and technology · 2014Trial
- Trial
- Overnight glucose control with an automated, unified safety system in children and adolescents with type 1 diabetes at diabetes camp.Diabetes care · 2014Trial
- Adding heart rate signal to a control-to-range artificial pancreas system improves the protection against hypoglycemia during exercise in type 1 diabetes.Diabetes technology & therapeutics · 2014Trial
- Safety of outpatient closed-loop control: first randomized crossover trials of a wearable artificial pancreas.Diabetes care · 2014Trial
- Autonomous and continuous adaptation of a bihormonal bionic pancreas in adults and adolescents with type 1 diabetes.The Journal of clinical endocrinology and metabolism · 2014Trial
- An integrated multivariable artificial pancreas control system.Journal of diabetes science and technology · 2014Trial
- Artificial pancreas using a personalized rule-based controller achieves overnight normoglycemia in patients with type 1 diabetes.Diabetes technology & therapeutics · 2014Trial
- Overnight closed-loop insulin delivery in young people with type 1 diabetes: a free-living, randomized clinical trial.Diabetes care · 2014Trial
- Trial
75 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
21 authors at 7 institutions in 3 countries.
Funding
Abstract
Integrated closed-loop control (CLC), combining continuous glucose monitoring (CGM) with insulin pump (continuous subcutaneous insulin infusion [CSII]), known as artificial pancreas, can help optimize glycemic control in diabetes. We present a fundamental modular concept for CLC design, illustrated by clinical studies involving 11 adolescents and 27 adults at the Universities of Virginia, Padova, and Montpellier. We tested two modular CLC constructs: standard control to range (sCTR), designed to augment pump plus CGM by preventing extreme glucose excursions; and enhanced control to range (eCTR), designed to truly optimize control within near normoglycemia of 3.9-10 mmol/L. The CLC system was fully integrated using automated data transfer CGM→algorithm→CSII. All studies used randomized crossover design comparing CSII versus CLC during identical 22-h hospitalizations including meals, overnight rest, and 30-min exercise. sCTR increased significantly the time in near normoglycemia from 61 to 74%, simultaneously reducing hypoglycemia 2.7-fold. eCTR improved mean blood glucose from 7.73 to 6.68 mmol/L without increasing hypoglycemia, achieved 97% in near normoglycemia and 77% in tight glycemic control, and reduced variability overnight. In conclusion, sCTR and eCTR represent sequential steps toward automated CLC, preventing extremes (sCTR) and further optimizing control (eCTR). This approach inspires compelling new concepts: modular assembly, sequential deployment, testing, and clinical acceptance of custom-built CLC systems tailored to individual patient needs.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.