ArticleDiabetes2012
Inhibition of TNF-α improves the bladder dysfunction that is associated with type 2 diabetes.
Article in Diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 69 citations in OpenAlex.
- From pharmacological management to regenerative medicine: a bibliometric analysis of global trends and evolutionary patterns in diabetic bladder dysfunction (2000-2024).Translational andrology and urology · 2026Article
- The Interaction Between Mitophagy Dysregulation and the Diabetic Bladder Microenvironment.Journal of diabetes · 2026Review
- Association of systemic immune-inflammatory index with stress urinary incontinence in U.S. Adults: NHANES 2007-2016.PloS one · 2026Article
- U‑shaped association between relative fat mass (RFM) and stress urinary incontinence: a cross‑sectional study.European journal of medical research · 2025Article
- Exploring the relationship between appendicular skeletal muscle index and urge urinary incontinence risk in adult women: a cross-sectional analysis of the National Health and Nutrition Examination Survey.Frontiers in nutrition · 2025Article
- The relationship between increased regional body fat and overactive bladder: a population-based study.Journal of health, population, and nutrition · 2024Article
- Association between lipid accumulation products and stress urinary incontinence: a cross-sectional study from NHANES 2005 to 2018.Lipids in health and disease · 2024Article
- Methylglyoxal and Advanced Glycation End Products (AGEs): Targets for the Prevention and Treatment of Diabetes-Associated Bladder Dysfunction?Biomedicines · 2024Review
- U-shaped association between serum 25-hydroxyvitamin D concentrations and urinary leakage among adult females aged 45 years and over in the United States: a cross-sectional study.BMC women's health · 2024Article
- Total muscle-to-fat ratio influences urinary incontinence in United States adult women: a population-based study.Frontiers in endocrinology · 2024Article
- PDE5 inhibitor potentially improves polyuria and bladder storage and voiding dysfunctions in type 2 diabetic rats.PloS one · 2024Article
- Composite dietary antioxidant index in relation to urge urinary incontinence in US men.Frontiers in nutrition · 2024Article
- Association of detrusor underactivity with aging and metabolic syndrome: suggestions from animal models.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2024Review
- Article
- Association between body mass index, trunk and total body fat percentage with urinary incontinence in adult US population.International urogynecology journal · 2023Article
- Anti-inflammation properties of resveratrol in the detrusor smooth muscle of the diabetic rat.International urology and nephrology · 2022Article
- Established and emerging treatments for diabetes-associated lower urinary tract dysfunction.Naunyn-Schmiedeberg's archives of pharmacology · 2022Review
- Inflammation triggered by the NLRP3 inflammasome is a critical driver of diabetic bladder dysfunction.Frontiers in physiology · 2022Review
- Associations between the dietary inflammatory index and urinary incontinence among women younger than 65 years.Scientific reports · 2021Article
- Attenuated regulatory function of the small-conductance CaInternational urology and nephrology · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
Diabetic bladder dysfunction (DBD) is common and affects 80% of diabetic patients. However, the molecular mechanisms underlying DBD remain elusive because of a lack of appropriate animal models. We demonstrate DBD in a mouse model that harbors hepatic-specific insulin receptor substrate 1 and 2 deletions (double knockout [DKO]), which develops type 2 diabetes. Bladders of DKO animals exhibited detrusor overactivity at an early stage: increased frequency of nonvoiding contractions during bladder filling, decreased voided volume, and dispersed urine spot patterns. In contrast, older animals with diabetes exhibited detrusor hypoactivity, findings consistent with clinical features of diabetes in humans. The tumor necrosis factor (TNF) superfamily genes were upregulated in DKO bladders. In particular, TNF-α was upregulated in serum and in bladder smooth muscle tissue. TNF-α augmented the contraction of primary cultured bladder smooth muscle cells through upregulating Rho kinase activity and phosphorylating myosin light chain. Systemic treatment of DKO animals with soluble TNF receptor 1 (TNFRI) prevented upregulation of Rho A signaling and reversed the bladder dysfunction, without affecting hyperglycemia. TNFRI combined with the antidiabetic agent, metformin, improved DBD beyond that achieved with metformin alone, suggesting that therapies targeting TNF-α may have utility in reversing the secondary urologic complications of type 2 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.