ArticleHormones and behavior2012
Experience-facilitated improvements in pup retrieval; evidence for an epigenetic effect.
Article in Hormones and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 88 citations in OpenAlex.
- Multiparity alters expression of corticotropin releasing factor receptor 1 and co-expression with oxytocin neurons in mice.Hormones and behavior · 2025Article
- Gestational immune activation disrupts hypothalamic neurocircuits of maternal care behavior.Molecular psychiatry · 2024Article
- Article
- Transcription and DNA methylation signatures of paternal behavior in hippocampal dentate gyrus of prairie voles.Scientific reports · 2023Article
- BAMBI: A new method for automated assessment of bidirectional early-life interaction between maternal behavior and pup vocalization in mouse dam-pup dyads.Frontiers in behavioral neuroscience · 2023Article
- Hearing Vocalizations during First Social Experience with Pups Increase Bdnf Transcription in Mouse Auditory Cortex.Neural plasticity · 2023Article
- Effects of maternal experience on pup-induced activation of maternal neural circuits in virgin mice.Hormones and behavior · 2022Article
- An epigenomic shift in amygdala marks the transition to maternal behaviors in alloparenting virgin female mice.PloS one · 2022Article
- A Scientometric Approach to Review the Role of the Medial Preoptic Area (MPOA) in Parental Behavior.Brain sciences · 2021Review
- The brain-placental axis: Therapeutic and pharmacological relevancy to pregnancy.Pharmacological research · 2019Review
- Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors.Neuroscience and biobehavioral reviews · 2019Review
- Histone deacetylase inhibitor treatment promotes spontaneous caregiving behaviour in non-aggressive virgin male mice.Journal of neuroendocrinology · 2019Review
- Mothers, Fathers, and Others: Neural Substrates of Parental Care.Trends in neurosciences · 2019Review
- Pharmacological manipulation of DNA methylation normalizes maternal behavior, DNA methylation, and gene expression in dams with a history of maltreatment.Scientific reports · 2019Article
- Experience-dependent mechanisms in the regulation of parental care.Frontiers in neuroendocrinology · 2019Review
- Capacities and neural mechanisms for auditory statistical learning across species.Hearing research · 2019Review
- Evidence for functional interactions between the placenta and brain in pregnant mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Histone deacetylase inhibitor treatment induces postpartum-like maternal behavior and immediate early gene expression in the maternal neural pathway in virgin mice.Hormones and behavior · 2019Article
- Epigenetic dysregulation of Oxtr in Tet1-deficient mice has implications for neuropsychiatric disorders.JCI insight · 2018Article
- Effects of social defeat on paternal behavior and pair bonding behavior in male California mice (Peromyscus californicus).Hormones and behavior · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The quality and quantity of maternal care received during infancy are highly predictive of successful infant development. It has been well established, primarily in rats, that the combination of hormonal and infant stimuli at birth modifies neural circuits that regulate maternal responsiveness. During subsequent interactions, infant stimuli are more likely to elicit rapid maternal responsiveness. Some species, such as humans, can display maternal care in the absence of the endocrine events of pregnancy and birth. Similarly, virgin C57BL/6J female mice, display maternal care toward infants, and experience with infants elicits long-lasting increases in maternal care. We hypothesized that these experience-induced changes in behavior may be mediated by chromatin modifications, which in turn change expression of genes that promote maternal care. One site of action is the medial preoptic area (MPOA). To test our hypothesis we treated virgin female mice with sodium butyrate, a histone deacetylase inhibitor. This treatment potentiated maternal responsiveness as well as the expression of several genes: estrogen receptor β (Esr2), oxytocin (Oxt), and cyclicAMP response element binding protein (CREB) binding protein (Crebbp; a histone acetyltransferase) in the MPOA. These data suggest that experience induces high levels of maternal care via epigenetic modifications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.