Evidence map›Paper›PMID 22687277›Full record

ArticleCold Spring Harbor perspectives in biology2012

Genomic imprinting and epigenetic control of development.

Andrew Fedoriw, Joshua Mugford, Terry Magnuson

Abstract read
In one paragraph

Article in Cold Spring Harbor perspectives in biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
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  11. Article
  12. Article
  13. Reports of biochemistry & molecular biology · 2020
    Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Epigenetic dysfunctional diseases and therapy for infection and inflammation.Biochimica et biophysica acta. Molecular basis of disease · 2017
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andrew FedoriwThe University of North Carolina at Chapel Hill School of Medicine, Department of Genetics, Chapel Hill, North Carolina 27599, USA.
Joshua Mugford
Terry Magnuson

Funding

Albino Deletion Complex and Early Mouse DevelopmentR01GM101974 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAGNUSON, TERRY R · 2012 to 2024
$5.2M
NIGMS NIH HHS R01 GM101974
6 · The paper itself

Abstract

Epigenetic mechanisms are extensively utilized during mammalian development. Specific patterns of gene expression are established during cell fate decisions, maintained as differentiation progresses, and often augmented as more specialized cell types are required. Much of what is known about these mechanisms comes from the study of two distinct epigenetic phenomena: genomic imprinting and X-chromosome inactivation. In the case of genomic imprinting, alleles are expressed in a parent-of-origin-dependent manner, whereas X-chromosome inactivation in females requires that only one X chromosome is active in each somatic nucleus. As model systems for epigenetic regulation, genomic imprinting and X-chromosome inactivation have identified and elucidated the numerous regulatory mechanisms that function throughout the genome during development.

Indexed as

Epigenesis, GeneticGenomic ImprintingAnimalsGerm CellsHumansX Chromosome Inactivation

Identifiers

PMID22687277
PMCPMC3385953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.