ArticleJournal of psychiatry & neuroscience : JPN2013
Structural brain correlates of sensorimotor gating in antipsychotic-naive men with first-episode schizophrenia.
Article in Journal of psychiatry & neuroscience : JPN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Neural mapping of prepulse-induced startle reflex modulation as indices of sensory information processing in healthy and clinical populations: A systematic review.Human brain mapping · 2021Pooled it
- Meta-Analysis of Sensorimotor Gating Deficits in Patients With Schizophrenia Evaluated by Prepulse Inhibition Test.Schizophrenia bulletin · 2020Pooled it
- Frontal D2/3 Receptor Availability in Schizophrenia Patients Before and After Their First Antipsychotic Treatment: Relation to Cognitive Functions and Psychopathology.The international journal of neuropsychopharmacology · 2016Trial
- Clonidine normalizes sensorimotor gating deficits in patients with schizophrenia on stable medication.Schizophrenia bulletin · 2013Trial
- Reduced brain structural similarity is associated with maturation, neurobiological features, and clinical status in schizophrenia.Nature communications · 2025Article
- Startle response and its prepulse modification in health and under different psychopathologies: Could we find any specific patterns?World journal of psychiatry · 2025Review
- Aberrant Dopamine System Function in the Ferrous Amyloid Buthionine (FAB) Rat Model of Alzheimer's Disease.International journal of molecular sciences · 2023Article
- Altered EEG, disrupted hippocampal long-term potentiation and neurobehavioral deficits implicate a delirium-like state in a mouse model of sepsis.Brain, behavior, and immunity · 2023Article
- Early Schizophrenia and Bipolar Disorder Patients Display Reduced Neural Prepulse Inhibition.Brain sciences · 2022Article
- Adolescent stress during, but not after, pubertal onset impairs indices of prepulse inhibition in adult rats.Developmental psychobiology · 2021Article
- Deficient prepulse inhibition in schizophrenia in a multi-site cohort: Internal replication and extension.Schizophrenia research · 2018Article
- Mismatch Negativity in Han Chinese Patients with Schizophrenia: A Meta-Analysis.Shanghai archives of psychiatry · 2017Review
- Chronic mild stress impairs latent inhibition and induces region-specific neural activation in CHL1-deficient mice, a mouse model of schizophrenia.Behavioural brain research · 2017Article
- Altered functional connectivity of the cingulate subregions in schizophrenia.Translational psychiatry · 2015Article
- Partial genetic deletion of neuregulin 1 modulates the effects of stress on sensorimotor gating, dendritic morphology, and HPA axis activity in adolescent mice.Schizophrenia bulletin · 2014Article
- Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Review
- Deficient prepulse inhibition in schizophrenia detected by the multi-site COGS.Schizophrenia research · 2014Article
- Brain mechanisms for prepulse inhibition in adults with Tourette syndrome: initial findings.Psychiatry research · 2013Article
- Impaired interval timing and spatial-temporal integration in mice deficient in CHL1, a gene associated with schizophrenia.Timing & time perception (Leiden, Netherlands) · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrepulse inhibition (PPI) of the startle reflex is modulated by a complex neural network. Prepulse inhibition impairments are found at all stages of schizophrenia. Previous magnetic resonance imaging (MRI) studies suggest that brain correlates of PPI differ between patients with schizophrenia and healthy controls; however, these studies included only patients with chronic illness and medicated patients. Our aim was to examine the structural brain correlates of PPI in antipsychotic-naive patients with first-episode schizophrenia.
methodsWe performed acoustic PPI assessment and structural MRI (1.5 and 3 T) in men with first-episode schizophrenia and age-matched controls. Voxel-based morphometry was used to investigate the association between PPI and grey matter volumes.
resultsWe included 27 patients and 38 controls in the study. Patients had lower PPI than controls. The brain areas in which PPI and grey matter volume correlated did not differ between the groups. Independent of group, PPI was significantly and positively associated with regional grey matter volume in the right superior parietal cortex. Prepulse inhibition and grey matter volume associations were also observed in the left rostral dorsal premotor cortex, the right presupplementary motor area and the anterior medial superior frontal gyrus bilaterally. Follow-up analyses suggested that the rostral dorsal premotor cortex and presupplementary motor area correlations were driven predominantly by the controls. LIMITATIONS: We used 2 different MRI scanners, which might have limited our ability to find subcortical associations since interscanner consistency is low for subcortical regions.
conclusionThe superior parietal cortex seems to be involved in the regulation of PPI in controls and antipsychotic-naive men with first-episode schizophrenia. Our observation that PPI deficits in schizophrenia may be related to the rostral dorsal premotor cortex and presupplementary motor area, brain areas involved in maintaining relevant sensory information and voluntary inhibition, warrants further study.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.