ArticleJournal of the American Chemical Society2012
Generation of thiocillin ring size variants by prepeptide gene replacement and in vivo processing by Bacillus cereus.
Article in Journal of the American Chemical Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- De novo design of ribosomally synthesized and post-translationally modified peptides.Nature chemistry · 2025Article
- Impact ofMicroorganisms · 2023Article
- Thiocillin contributes to the ecological fitness ofFrontiers in microbiology · 2023Article
- De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors.Journal of the American Chemical Society · 2022Article
- New developments in RiPP discovery, enzymology and engineering.Natural product reports · 2021Review
- Interception of the Bycroft-Gowland Intermediate in the Enzymatic Macrocyclization of Thiopeptides.Journal of the American Chemical Society · 2020Article
- Minimal lactazole scaffold for in vitro thiopeptide bioengineering.Nature communications · 2020Article
- Dehydroamino acids: chemical multi-tools for late-stage diversification.Organic & biomolecular chemistry · 2019Review
- Investigations into PoyH, a promiscuous protease from polytheonamide biosynthesis.Journal of industrial microbiology & biotechnology · 2019Article
- Thiopeptide Pyridine Synthase TbtD Catalyzes an Intermolecular Formal Aza-Diels-Alder Reaction.Journal of the American Chemical Society · 2019Article
- RiPP antibiotics: biosynthesis and engineering potential.Current opinion in microbiology · 2018Review
- Characterization of Leader Peptide Binding During Catalysis by the Nisin Dehydratase NisB.Journal of the American Chemical Society · 2018Article
- Elucidating and engineering thiopeptide biosynthesis.World journal of microbiology & biotechnology · 2017Review
- YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.Chemical reviews · 2017Review
- Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product.Journal of the American Chemical Society · 2017Article
- Reconstitution and Minimization of a Micrococcin Biosynthetic Pathway in Bacillus subtilis.Journal of bacteriology · 2016Article
- In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products.ACS chemical biology · 2016Article
- Recent advances of Diels-Alderases involved in natural product biosynthesis.The Journal of antibiotics · 2016Review
- Thiostrepton Variants Containing a Contracted Quinaldic Acid Macrocycle Result from Mutagenesis of the Second Residue.ACS chemical biology · 2016Article
- Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A.ACS chemical biology · 2015Article
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Authors and funding
4 authors.
Funding
Abstract
The thiocillins from Bacillus cereus ATCC 14579 are natural products from the broader class of thiazolyl peptides. Their biosynthesis proceeds via extensive post-translational modification of a ribosomally encoded precursor peptide. This post-translational tailoring involves a key step formal cycloaddition between two distal serine residues. In the wild-type structure, this cycloaddition forms a major macrocycle circumscribed by 26-atoms (shortest path). Results presented herein demonstrate the promiscuity of this last step by means of a set of "competition" experiments. Cyclization proceeds in many cases to provide altered ring sizes, giving access to several variant rings sizes that have not previously been observed in nature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.