Evidence map›Paper›PMID 22686623›Full record

ReviewJournal of aerosol medicine and pulmonary drug delivery2012

Aerosol deposition in health and disease.

Chantal Darquenne

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of aerosol medicine and pulmonary drug delivery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 143 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
143citing papers in PubMed, 2 pooled it
11.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

143 citing papers in PubMed, 2 syntheses or guidelines pooled it, 425 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. A Trans-Nasal Aerosol Delivery Device for Efficient Pulmonary Deposition.Journal of aerosol medicine and pulmonary drug delivery · 2017
    Trial
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  19. Advances in Inhaled Nanoparticle Drug Delivery for Pulmonary Disease Management.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
    Review
  20. Article

83 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Chantal DarquenneDepartment of Medicine, University of California, San Diego, La Jolla, CA 92093-0623, USA. cdarquenne@ucsd.edu
University of California, San Diego · US

Funding

Modeling of Aerosol Transport in Alveolated AirwaysR01ES011177 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DARQUENNE, CHANTAL · 2001 to 2009
$1.8M
NIEHS NIH HHS ES011177NIEHS NIH HHS R01 ES011177
6 · The paper itself

Abstract

The success of inhalation therapy is not only dependent upon the pharmacology of the drugs being inhaled but also upon the site and extent of deposition in the respiratory tract. This article reviews the main mechanisms affecting the transport and deposition of inhaled aerosol in the human lung. Aerosol deposition in both the healthy and diseased lung is described mainly based on the results of human studies using nonimaging techniques. This is followed by a discussion of the effect of flow regime on aerosol deposition. Finally, the link between therapeutic effects of inhaled drugs and their deposition pattern is briefly addressed. Data show that total lung deposition is a poor predictor of clinical outcome, and that regional deposition needs to be assessed to predict therapeutic effectiveness. Indeed, spatial distribution of deposited particles and, as a consequence, drug efficiency is strongly affected by particle size. Large particles (>6 μm) tend to mainly deposit in the upper airway, limiting the amount of drugs that can be delivered to the lung. Small particles (<2 μm) deposit mainly in the alveolar region and are probably the most apt to act systemically, whereas the particle in the size range 2-6 μm are be best suited to treat the central and small airways.

Indexed as

AerosolsDiffusionHumansLungParticle SizeAerosols

Identifiers

PMID22686623
PMCPMC3417302
OpenAlexW2040017474

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.