ArticleJournal of veterinary internal medicine
Broadly reactive polymerase chain reaction for pathogen detection in canine granulomatous meningoencephalomyelitis and necrotizing meningoencephalitis.
Article in Journal of veterinary internal medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 59 citations in OpenAlex.
- Allele frequency of a genetic risk variant for necrotizing meningoencephalitis in pug dogs from Europe and association with the clinical phenotype.Frontiers in veterinary science · 2024Article
- Case report: Necrotizing leukomyelitis and meningitis in a Pomeranian.Frontiers in veterinary science · 2024Article
- Of potential new treatment targets and polythetic approach in meningoencephalitis of unknown origin: a review.Frontiers in veterinary science · 2024Review
- Investigation of side effects to treatment and cause of death in 63 Scandinavian dogs suffering from meningoencephalitis of unknown origin: a retrospective study.Acta veterinaria Scandinavica · 2023Article
- Predictive Value of Acute Phase Proteins for the Short-Term Outcome of Meningoencephalitis of Unknown Origin in Dogs.Animals : an open access journal from MDPI · 2023Article
- New insights into the treatment of meningoencephalomyelitis of unknown origin since 2009: A review of 671 cases.Frontiers in veterinary science · 2023Review
- Neuroinflammatory diseases of the central nervous system of dogs: A retrospective study of 207 cases (2008-2019).The Canadian veterinary journal = La revue veterinaire canadienne · 2022Article
- Concomitant necrotizing encephalitis and granulomatous meningoencephalitis in four toy breed dogs.Frontiers in veterinary science · 2022Article
- Case report: Lympho-histiocytic meningoencephalitis with central nervous system vasculitis of unknown origin in three dogs.Frontiers in veterinary science · 2022Article
- Screening for Viral Nucleic Acids in the Cerebrospinal Fluid of Dogs With Central Nervous System Inflammation.Frontiers in veterinary science · 2022Article
- Meningeal B Cell Clusters Correlate with Submeningeal Pathology in a Natural Model of Multiple Sclerosis.Journal of immunology (Baltimore, Md. : 1950) · 2021Article
- Role ofMicroorganisms · 2021Article
- Inflammatory Disease Affecting the Central Nervous System in Dogs: A Retrospective Study in England (2010-2019).Frontiers in veterinary science · 2021Article
- Canine Meningoencephalitis of Unknown Origin-The Search for Infectious Agents in the Cerebrospinal Fluid via Deep Sequencing.Frontiers in veterinary science · 2021Article
- Efficacy data of halogenated phenazine and quinoline agents and an NH125 analogue to veterinary mycoplasmas.BMC veterinary research · 2020Article
- Investigation of astrovirus and bornavirus in the cerebrospinal fluid of dogs clinically diagnosed with meningoencephalitis of unknown etiology.Journal of veterinary internal medicine · 2020Article
- Central nervous system diseases of cattle in Georgia, 2001-2017.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2019Article
- Immune-Mediated Central Nervous System Disease-Current Knowledge and Recommendations.Topics in companion animal medicine · 2019Review
- Prognostic Factors for Recovery of Vision in Canine Optic Neuritis of Unknown Etiology: 26 Dogs (2003-2018).Frontiers in veterinary science · 2019Article
- Testing for Bartonella ssp. DNA in cerebrospinal fluid of dogs with inflammatory central nervous system disease.Journal of veterinary internal medicine · 2018Article
Corrections and comments
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Authors and funding
13 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundGranulomatous meningoencephalomyelitis (GME) and necrotizing meningoencephalitis (NME) are common inflammatory conditions of the central nervous system of dogs. Infectious pathogens, particularly viruses, are suspected to contribute to the etiopathogenesis of GME and NME. HYPOTHESIS: Broadly reactive PCR might aid in the identification of infectious agents in GME and NME. ANIMALS: Sixty-eight client-owned dogs evaluated by necropsy at 1 university referral hospital.
methodsA mixed prospective/retrospective case-control study was performed. Brain tissue prospectively collected at necropsy from GME, NME, and control cases was evaluated by broadly reactive polymerase chain reaction (PCR) for adenoviruses, bunyaviruses, coronaviruses, enteroviruses, flaviviruses, herpesviruses, paramyxoviruses, and parechoviruses. In addition, these tissues were retrospectively evaluated for the presence of mycoplasmas by PCR, culture, and immunohistochemistry (IHC).
resultsBrain tissue was collected from 11 GME and 27 NME cases and 30 controls. Viral nucleic acids were not identified in the 6 GME cases, 25 NME cases, and 2 controls evaluated by viral PCR. Mycoplasma canis was identified by Mycoplasma genus PCR in 1/5 GME and 4/25 NME cases and subsequently was cultured from 4/5 GME and 4/8 NME cases as well as 2/9 controls. The IHC did not detect M. canis in any of the 11 GME and 27 NME cases or 14 controls evaluated with strain PG14 polyclonal antiserum. CONCLUSIONS AND CLINICAL IMPORTANCE: The negative results suggest that viral pathogens are not common in the brain tissue of dogs with GME and NME. Further investigation is warranted to determine the importance of M . canis in cases of GME and NME.
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