ArticleMolecular ecology2012
Spatially and temporally varying selection on intrapopulation quantitative trait loci for a life history trade-off in Mimulus guttatus.
Article in Molecular ecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 104 citations in OpenAlex.
- Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China.International journal of molecular sciences · 2018Trial
- Unique genetic bases of repeated life-history divergence associated with high altitude adaptation inbioRxiv : the preprint server for biology · 2025Article
- Heat waves decrease fitness and alter maternal provisioning in natural populations of Mimulus guttatus.American journal of botany · 2025Article
- It's all in the timing: vegetative phase change alters selection under drought and contributes to local adaptation.bioRxiv : the preprint server for biology · 2025Article
- Among- and within-population variation in germination response shapes ecological resilience in the Mediterranean cliff species Brassica incana.Annals of botany · 2025Article
- The quantitative genetics of gene expression in Mimulus guttatus.PLoS genetics · 2024Article
- Dominance reversals: the resolution of genetic conflict and maintenance of genetic variation.Proceedings. Biological sciences · 2024Review
- Postzygotic barriers persist despite ongoing introgression in hybridizing Mimulus species.Molecular ecology · 2024Article
- PeCIN8 expression correlates with flower size and resistance to yellow leaf disease in Phalaenopsis orchids.BMC plant biology · 2023Article
- Demographic consequences of an extreme heat wave are mitigated by spatial heterogeneity in an annual monkeyflower.Ecology and evolution · 2023Article
- No evidence for schistosome parasite fitness trade-offs in the intermediate and definitive host.Parasites & vectors · 2023Article
- Spatially and temporally varying selection influence species boundaries in two sympatricProceedings. Biological sciences · 2023Article
- Newly identified sex chromosomes in the Sphagnum (peat moss) genome alter carbon sequestration and ecosystem dynamics.Nature plants · 2023Article
- Invasive success of star weed (PeerJ · 2023Article
- Natural selection fluctuates at an extremely fine spatial scale inside a wild population of snapdragon plants.Evolution; international journal of organic evolution · 2022Article
- The genetic architecture and evolution of life-history divergence among perennials in theProceedings. Biological sciences · 2021Article
- Predicting evolutionary change at the DNA level in a natural Mimulus population.PLoS genetics · 2021Article
- Genotype-environment interaction and the maintenance of genetic variation: an empirical study ofRoyal Society open science · 2020Article
- Balancing selection via life-history trade-offs maintains an inversion polymorphism in a seaweed fly.Nature communications · 2020Article
- Divergence in drought-response traits between sympatric species ofEcology and evolution · 2019Article
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4 authors at 2 institutions in 1 country.
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Abstract
Why do populations remain genetically variable despite strong continuous natural selection? Mutation reconstitutes variation eliminated by selection and genetic drift, but theoretical and experimental studies each suggest that mutation-selection balance insufficient to explain extant genetic variation in most complex traits. The alternative hypothesis of balancing selection, wherein selection maintains genetic variation, is an aggregate of multiple mechanisms (spatial and temporal heterogeneity in selection, frequency-dependent selection, antagonistic pleiotropy, etc.). Most of these mechanisms have been demonstrated for Mendelian traits, but there is little comparable data for loci affecting quantitative characters. Here, we report a 3-year field study of selection on intrapopulation quantitative trait loci (QTL) of flower size, a highly polygenic trait in Mimulus guttatus. The QTL exhibit antagonistic pleiotropy: alleles that increase flower size, reduce viability, but increase fecundity. The magnitude and direction of selection fluctuates yearly and on a spatial scale of metres. This study provides direct evidence of balancing selection mechanisms on QTL of an ecologically relevant trait.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.