ArticlePaediatric and perinatal epidemiology2012
NICU Network Neurobehavioral Scale profiles predict developmental outcomes in a low-risk sample.
Article in Paediatric and perinatal epidemiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00129324 (Neurobehavioral Effects of Prevalent Neurotoxicants in Children), which is not on this map. Cited by 53 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neurobehavioral Effects of Prevalent Neurotoxicants in Children: A Cohort Study of the Cincinnati Center for Children's Environmental Health
Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Infant neurobehavioural consequences of prenatal cigarette exposure: A systematic review and meta-analysis.Acta paediatrica (Oslo, Norway : 1992) · 2020Pooled it
- Selenium-associated DNA methylation modifications in placenta and neurobehavioral development of newborns: An epigenome-wide study of two U.S. birth cohorts.Environment international · 2020Pooled it
- Epigenome-wide Analysis Identifies Genes and Pathways Linked to Neurobehavioral Variation in Preterm Infants.Scientific reports · 2019Trial
- Associations between maternal emotion dysregulation, infant negative affect and toddler mental health depend on newborn neurobehavioral profiles.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Neonatal neurobehavior: a tale of two scales contrasting the NICU Network Neurobehavioral Scale with the NeoNatal Neurobehavioral Scale.Pediatric research · 2026Article
- Association between NNNS-II profiles and pharmacological treatment in infants with prenatal opioid exposure.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Association between NNNS-II Profiles and Pharmacological Treatment in Infants with Prenatal Opioid Exposure.Research square · 2025Article
- Neurobehavioral Profiles in Low-Risk Infants: Associations With Prenatal Maternal Biobehavior and Birth Characteristics.Developmental psychobiology · 2025Article
- Neonatal neurobehavior and infant temperament amongst offspring born to parents with and without ADHD.Infant behavior & development · 2025Article
- Neurobehavioral Profiles in Opioid-Exposed and Unexposed Neonates.The Journal of pediatrics · 2025Observational
- Impact of prenatal phthalate exposure on newborn metabolome and infant neurodevelopment.Nature communications · 2025Article
- Abnormal neurobehavior profiles observed in the newborn period following low-to-moderate prenatal alcohol exposure.Alcohol, clinical & experimental research · 2025Article
- Neurobehavioral outcomes of preterm infants: toward a holistic approach.Pediatric research · 2025Review
- Neuromotor effects of early-life exposure to a mixture of endocrine disruptors in Belgian preschool children.Environmental health : a global access science source · 2025Article
- Evidence for neurobehavioral risk phenotypes at birth.Pediatric research · 2025Review
- Differential item functioning in neonatal behavioral neurological assessment in high-risk full-term infants in NICU based on a machine learning approach.Frontiers in neuroscience · 2025Article
- Factors affecting feeding ability in children with neonatal intensive care unit stay: a cluster analysis using machine learning methods.Frontiers in pediatrics · 2025Article
- Maternal symptoms of depression and anxiety as modifiers of the relationship between prenatal phthalate exposure and infant neurodevelopment in the Atlanta African American maternal-child cohort.Brain, behavior, & immunity - health · 2024Article
- Prenatal and perinatal exposure to Per- and polyfluoroalkyl substances (PFAS)-contaminated drinking water impacts offspring neurobehavior and development.The Science of the total environment · 2024Article
- Prenatal and perinatal factors associated with neonatal neurobehavioral profiles in the ECHO Program.Pediatric research · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundLatent profile analysis (LPA) has been used previously to classify neurobehavioral responses of infants prenatally exposed to cocaine and other drugs of abuse. The objective of this study was to define NICU Network Neurobehavioral Scale (NNNS) profile response patterns in a cohort of infants with no known cocaine exposure or other risks for neurobehavior deficits, and determine whether these profiles predict neurobehavioral outcomes in these low-risk infants.
methodsNNNS exams were performed on 355 low-risk infants at approximately 5 weeks after birth. LPA was used to define discrete profiles based on the standard NNNS summary scales. Associations between the infant profiles and neurobehavioral outcomes at one to three years of age were examined.
resultsTwelve of the 13 summary scales were used and three discrete NNNS profiles identified: social/easy going infants (44%), hypotonic infants (24%), and high arousal/difficult infants (32%). Statistically significant associations between NNNS profiles and later neurobehavioral outcomes were found for psychomotor development and externalizing behaviors. Hypotonic infants had both lower psychomotor development and lower externalizing scores compared to the other two profiles.
conclusionsThree distinct profiles of the NNNS summary scores were identifiable using LPA among infants with no known cocaine exposure. These profile patterns were associated with early childhood neurobehavioral outcome, similar to findings reported in a study of infants with substantial cocaine exposure, demonstrating the utility of this profiling technique in both exposed and unexposed populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.