ReviewClinical and translational science2012
Metabolomics as a key integrator for "omic" advancement of personalized medicine and future therapies.
Review in Clinical and translational science, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 51 citations in OpenAlex.
- A novel fasting blood test for insulin resistance and prediabetes.Journal of diabetes science and technology · 2013Trial
- Article
- Article
- Metabolomics analysis reveals cytotoxic effects of ouabain towards psoriatic keratinocytes via impairment of glutathione metabolism.Molecular genetics and genomics : MGG · 2023Article
- Age- and Sex-Dependent Changes of Free Circulating Blood Metabolite and Lipid Abundances, Correlations, and Ratios.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Biomarkers for the Clinical Diagnosis of Alzheimer's Disease: Metabolomics Analysis of Brain Tissue and Blood.Frontiers in pharmacology · 2021Review
- Differential Network Analysis Reveals Metabolic Determinants Associated with Mortality in Acute Myocardial Infarction Patients and Suggests Potential Mechanisms Underlying Different Clinical Scores Used To Predict Death.Journal of proteome research · 2020Article
- Serum Metabolomic Profiling Reveals the Amelioration Effect of Methotrexate on Imiquimod-Induced Psoriasis in Mouse.Frontiers in pharmacology · 2020Article
- Serum metabolites as predictive molecular markers of ovarian response to controlled stimulation: a pilot study.JBRA assisted reproduction · 2019Article
- Cheminformatics approach to exploring and modeling trait-associated metabolite profiles.Journal of cheminformatics · 2019Article
- NMR-based metabolomics identifies patients at high risk of death within two years after acute myocardial infarction in the AMI-Florence II cohort.BMC medicine · 2019Article
- Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis.Arthritis research & therapy · 2018Article
- Application of Metabolomics to Study Effects of Bariatric Surgery.Journal of diabetes research · 2018Review
- Critical Role of Glucose Metabolism in Rheumatoid Arthritis Fibroblast-like Synoviocytes.Arthritis & rheumatology (Hoboken, N.J.) · 2016Article
- Choline kinase inhibition in rheumatoid arthritis.Annals of the rheumatic diseases · 2015Article
- Metabolomics and its Application to the Development of Clinical Laboratory Tests for Prostate Cancer.EJIFCC · 2015Article
- Metabolomics profiling of pre-and post-anesthesia plasma samples of colorectal patients obtained via Ficoll separation.Metabolomics : Official journal of the Metabolomic Society · 2015Article
- Serum metabolic signatures of primary biliary cirrhosis and primary sclerosing cholangitis.Liver international : official journal of the International Association for the Study of the Liver · 2015Article
- Understanding the apothecaries within: the necessity of a systematic approach for defining the chemical output of the human microbiome.Clinical and translational science · 2014Review
- Metabolomics in psoriatic disease: pilot study reveals metabolite differences in psoriasis and psoriatic arthritis.F1000Research · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Investigation into biological complexity, whether for a better understanding of disease or drug process, is a monumental task plaguing investigators. The lure of "omic" technologies for circumventing much of these challenges has led to widespread efforts and adoption. It is becoming clearer that a single "omic" approach (e.g., genomics) is often insufficient for completely defining the complexity in these biological systems. Hence, there is an increasing awareness that a "systems" approach will serve to increase resolution and confidence and provide a strong foundation for further hypothesis-driven investigation. Although certain metabolites are already considered clinically important, the profiling of metabolites via metabolomics (the profiling of metabolites to fully characterize metabolic pathways) is the most recent to mature of these "omic" technologies and has been only recently adopted as compared to genomic or proteomic approaches in systems inquiries. Recent reports suggest that this "omic" may well be a key data stream in systems investigations for endeavors in personalized medicine and biomarker identification, as it seems most closely relevant to the phenotype.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.