ArticleInternational journal of nephrology2012
Congenital anomalies of the kidney and urinary tract: a genetic disorder?
Article in International journal of nephrology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 1 of them a synthesis that pooled it.
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Who cites it
55 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-term renal outcomes in children with posterior urethral valves: a systematic review and meta-analysis.Pediatric surgery international · 2026Pooled it
- Review
- Congenital anomalies of the kidney and urinary tract in Nigeria: a thirteen-year single centre review.BMC pediatrics · 2026Article
- Associations between biochemical parameters and oral health indices in pediatric chronic kidney disease: a cross-sectional study.BMC oral health · 2026Article
- The utility and advantages of exome and genome sequencing in pediatric kidney disease diagnosis.Childhood kidney diseases · 2026Review
- A review of congenital anomalies of the kidney and urinary tract (CAKUT) in Africa.Annals of medicine and surgery (2012) · 2026Review
- The relationship between the maternal consumption of barberry, saffron, pickled vegetables, and tea and the odds of congenital anomalies in Iranian children under 10 years of age: A case-control study.Journal of education and health promotion · 2025Article
- Risks of Renal Anomalies and Urinary Tract Infections in Neonates With Single Umbilical Artery.Cureus · 2024Article
- Determination of the Frequency of BCL-2 Polymorphisms (c.-717C>A and c.*2364G>A) and LIF Polymorphism (c.*1414T>G) in Patients with Congenital Anomalies of the Kidney and Urinary Tract.Molecular syndromology · 2024Article
- Immunoexpression Pattern of Autophagy-Related Proteins in Human Congenital Anomalies of the Kidney and Urinary Tract.International journal of molecular sciences · 2024Article
- Combined Minimally Invasive Treatment of Pyeloureteral Junction Obstruction and Primary Obstructive Megaureter in Children: Case Report and Literature Review.Children (Basel, Switzerland) · 2024Article
- Congenital anomalies of the kidney and urinary tract.Frontiers in medicine · 2024Review
- [Congenital anomalies of the kidneys and urinary tract (CAKUT) : Embryology in radiology and fetal magnetic resonance imaging].Radiologie (Heidelberg, Germany) · 2024Review
- Associations between maternal chronic diseases and congenital anomalies of the kidney and urinary tract in offspring: a population-based cohort study.Clinical kidney journal · 2023Article
- Fetal Renal Duplicated Collecting System at 14-16 Weeks of Gestation.Journal of clinical medicine · 2023Article
- Genetic spectrum of CAKUT and risk factors for kidney failure: a pediatric multicenter cohort study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2022Article
- The importance of CT Urography in early diagnosis of anatomical variations in urogenital tract: case presentation.Radiology case reports · 2022Article
- Long-term follow-up of congenital anomalies of the kidney and urinary tract diagnosed in utero: a longitudinal study.Journal of nephrology · 2022Article
- Single-cell RNA sequencing reveals differential cell cycle activity in key cell populations during nephrogenesis.Scientific reports · 2021Article
- ATDiabetologia · 2021Article
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Authors and funding
1 author.
Funding
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Abstract
Congenital anomalies of the kidney and urinary tract (CAKUTs) occur in 3-6 per 1000 live births, account for the most cases of pediatric end-stage kidney disease (ESKD), and predispose an individual to hypertension and cardiovascular disease throughout life. Although CAKUTs are a part of many known syndromes, only few single-candidate causative genes have been implicated so far in nonsyndromic cases of human CAKUT. Evidence from mouse models supports the hypothesis that non-syndromic human CAKUT may be caused by single-gene defects. Because increasing numbers of children with CAKUT are surviving to adulthood, better understanding of the molecular pathogenesis of CAKUT, development of new strategies aiming at prevention of CAKUT, preservation of renal function, and avoidance of associated cardiovascular morbidity are needed. In this paper, we will focus on the knowledge derived from the study of syndromic and non-syndromic forms of CAKUT in humans and mouse mutants to discuss the role of genetic, epigenetic, and in utero environmental factors in the pathogenesis of non-syndromic forms of CAKUT in children with particular emphasis on the genetic contributions to CAKUT.
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