ArticleNeurology research international2012
Modeling the encephalopathy of prematurity in animals: the important role of translational research.
Article in Neurology research international, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- A Comparison of Neurodevelopmental Outcomes of Late Preterm Infants with Healthy Full-term Infants at Imam Khomeini Hospital, 2019-2020.Journal of family & reproductive health · 2025Article
- Timed fetal inflammation and postnatal hypoxia cause cortical white matter injury, interneuron imbalances, and behavioral deficits in a double-hit rat model of encephalopathy of prematurity.Brain, behavior, & immunity - health · 2024Article
- Microstate Analysis Reflects Maturation of the Preterm Brain.Brain topography · 2024Article
- Developmental Brain Injury and Social Determinants of Health: Opportunities to Combine Preclinical Models for Mechanistic Insights into Recovery.Developmental neuroscience · 2023Review
- Comprehensive clinical, biochemical, radiological and genetic analysis of 28 Turkish cases with suspected metachromatic leukodystrophy and their relatives.Molecular genetics and metabolism reports · 2020Article
- Current Evidence on Cell Death in Preterm Brain Injury in Human and Preclinical Models.Frontiers in cell and developmental biology · 2020Review
- The Absence of TLR4 Prevents Fetal Brain Injury in the Setting of Intrauterine Inflammation.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Early neuropathological and neurobehavioral consequences of preterm birth in a rabbit model.Scientific reports · 2019Article
- Annexin A1 as Neuroprotective Determinant for Blood-Brain Barrier Integrity in Neonatal Hypoxic-Ischemic Encephalopathy.Journal of clinical medicine · 2019Article
- Association of impaired neuronal migration with cognitive deficits in extremely preterm infants.JCI insight · 2017Article
- Cerebral microbleeds in a neonatal rat model.PloS one · 2017Article
- Clinical neuroimaging in the preterm infant: Diagnosis and prognosis.NeuroImage. Clinical · 2017Review
- Glial progenitor cell-based treatment of the childhood leukodystrophies.Experimental neurology · 2016Review
- Prenatal ischemia deteriorates white matter, brain organization, and function: implications for prematurity and cerebral palsy.Developmental medicine and child neurology · 2016Review
- Early Postnatal Lipopolysaccharide Exposure Leads to Enhanced Neurogenesis and Impaired Communicative Functions in Rats.PloS one · 2016Article
- Preterm Hypoxic-Ischemic Encephalopathy.Frontiers in pediatrics · 2016Review
- Evolution of T1 Relaxation, ADC, and Fractional Anisotropy during Early Brain Maturation: A Serial Imaging Study on Preterm Infants.AJNR. American journal of neuroradiology · 2016Article
- Angiogenesis induced by prenatal ischemia predisposes to periventricular hemorrhage during postnatal mechanical ventilation.Pediatric research · 2015Article
- Blood-brain barrier dysfunction in disorders of the developing brain.Frontiers in neuroscience · 2015Review
- The challenge of understanding cerebral white matter injury in the premature infant.Neuroscience · 2014Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Translational research in preterm brain injury depends upon the delineation of the human neuropathology in order that animal models faithfully reiterate it, thereby ensuring direct relevance to the human condition. The major substrate of human preterm brain injury is the encephalopathy of prematurity that is characterized by gray and white matter lesions reflecting combined acquired insults, altered developmental trajectories, and reparative phenomena. Here we highlight the key features of human preterm brain development and the encephalopathy of prematurity that are critical for modeling in animals. The complete mimicry of the complex human neuropathology is difficult in animal models. Many models focus upon mechanisms related to a specific feature, for example, loss of premyelinating oligodendrocytes in the cerebral white matter. Nevertheless, animal models that simultaneously address oligodendrocyte, neuronal, and axonal injury carry the potential to decipher shared mechanisms and synergistic treatments to ameliorate the global consequences of the encephalopathy of prematurity.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.