ArticlePloS one2012
Magnetic hydroxyapatite bone substitutes to enhance tissue regeneration: evaluation in vitro using osteoblast-like cells and in vivo in a bone defect.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 114 citations in OpenAlex.
- Osteointegration of porous absorbable bone substitutes: A systematic review of the literature.Clinics (Sao Paulo, Brazil) · 2017Pooled it
- Wear, fatigue characteristics, and antibacterial performance of UHMWPE reinforced with HAP+TiOScientific reports · 2026Article
- Novel FeInternational journal of molecular sciences · 2024Article
- Magnetic Hydroxyapatite Nanoparticles in Regenerative Medicine and Nanomedicine.International journal of molecular sciences · 2024Review
- Advanced 3D Magnetic Scaffolds for Tumor-Related Bone Defects.International journal of molecular sciences · 2022Review
- Electrospun Biomimetic Nanofibrous Scaffolds: A Promising Prospect for Bone Tissue Engineering and Regenerative Medicine.International journal of molecular sciences · 2022Review
- One-Step Synthesis of Magnetic Nanocomposite with Embedded Biologically Active Substance.Molecules (Basel, Switzerland) · 2021Article
- Scaffold-based 3D cellular models mimicking the heterogeneity of osteosarcoma stem cell niche.Scientific reports · 2020Article
- Evidence of Modular Responsiveness of Osteoblast-Like Cells Exposed to Hydroxyapatite-Containing Magnetic Nanostructures.Biology · 2020Article
- Bone tissue regeneration: biology, strategies and interface studies.Progress in biomaterials · 2019Review
- Article
- Innovative Biomaterials for Bone Regrowth.International journal of molecular sciences · 2019Review
- A Graded Multifunctional Hybrid Scaffold with Superparamagnetic Ability for Periodontal Regeneration.International journal of molecular sciences · 2018Article
- Development of Magnetically Active Scaffolds for Bone Regeneration.Nanomaterials (Basel, Switzerland) · 2018Article
- Bone tissue engineering via growth factor delivery: from scaffolds to complex matrices.Regenerative biomaterials · 2018Review
- 3D Biomimetic Magnetic Structures for Static Magnetic Field Stimulation of Osteogenesis.International journal of molecular sciences · 2018Article
- Proliferation and differentiation of mesenchymal stem cells on scaffolds containing chitosan, calcium polyphosphate and pigeonite for bone tissue engineering.Cell proliferation · 2018Article
- Magnetic forces and magnetized biomaterials provide dynamic flux information during bone regeneration.Journal of materials science. Materials in medicine · 2016Article
- Multilayered Magnetic Gelatin Membrane Scaffolds.ACS applied materials & interfaces · 2015Article
- Highly Efficient Labeling of Human Lung Cancer Cells Using Cationic Poly-l-lysine-Assisted Magnetic Iron Oxide Nanoparticles.Nano-micro letters · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
In case of degenerative disease or lesion, bone tissue replacement and regeneration is an important clinical goal. In particular, nowadays, critical size defects rely on the engineering of scaffolds that are 3D structural supports, allowing cellular infiltration and subsequent integration with the native tissue. Several ceramic hydroxyapatite (HA) scaffolds with high porosity and good osteointegration have been developed in the past few decades but they have not solved completely the problems related to bone defects. In the present study we have developed a novel porous ceramic composite made of HA that incorporates magnetite at three different ratios: HA/Mgn 95/5, HA/Mgn 90/10 and HA/Mgn 50/50. The scaffolds, consolidated by sintering at high temperature in a controlled atmosphere, have been analysed in vitro using human osteoblast-like cells. Results indicate high biocompatibility, similar to a commercially available HA bone graft, with no negative effects arising from the presence of magnetite or by the use of a static magnetic field. HA/Mgn 90/10 was shown to enhance cell proliferation at the early stage. Moreover, it has been implanted in vivo in a critical size lesion of the rabbit condyle and a good level of histocompatibility was observed. Such results identify this scaffold as particularly relevant for bone tissue regeneration and open new perspectives for the application of a magnetic field in a clinical setting of bone replacement, either for magnetic scaffold fixation or magnetic drug delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.