Trial reportPloS one2012
Attentional set-shifting deficit in Parkinson's disease is associated with prefrontal dysfunction: an FDG-PET study.
Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Sternum-worn vibrotactile device in Parkinson's disease: a randomised, double-blind, placebo-controlled pilot trial.NPJ Parkinson's disease · 2026Article
- Diffusion tensor image analysis along the perivascular space (DTI-ALPS) in Parkinson's disease patients with subjective cognitive decline.Frontiers in aging neuroscience · 2026Article
- Theory of mind in mild cognitive impairment and Parkinson's disease: The role of memory impairment.Cognitive, affective & behavioral neuroscience · 2024Article
- Stress-inducible phosphoprotein 1 (HOP/STI1/STIP1) regulates the accumulation and toxicity of α-synuclein in vivo.Acta neuropathologica · 2022Article
- Cortical Serotonergic and Catecholaminergic Denervation in MPTP-Treated Parkinsonian Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Exploring reward-related attention selectivity deficits in Parkinson's disease.Scientific reports · 2021Article
- The individual and combined effects of spaceflight radiation and microgravity on biologic systems and functional outcomes.Journal of environmental science and health. Part C, Toxicology and carcinogenesis · 2021Article
- Correlations of Neuropsychological and Metabolic Brain Changes in Parkinson's Disease and Other α-Synucleinopathies.Frontiers in neurology · 2019Review
- Article
- Differential Contributions of Ventral and Dorsal Striatum to Early and Late Phases of Cognitive Set Reconfiguration.Journal of cognitive neuroscience · 2016Article
- The Therapeutic Potential of Exercise to Improve Mood, Cognition, and Sleep in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2016Review
- Perceptual, cognitive, and personality rigidity in Parkinson's disease.Neuropsychologia · 2015Article
- The neural correlates of spatial and object working memory in elderly and Parkinson's disease subjects.Behavioural neurology · 2015Article
- Performance of C57BL/6J and DBA/2J mice on a touchscreen-based attentional set-shifting task.Behavioural brain research · 2014Article
- Striatal volume is related to phonemic verbal fluency but not to semantic or alternating verbal fluency in early Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2014Article
- Emotion regulation strategies can predict task-switching abilities in euthymic bipolar patients.Frontiers in human neuroscience · 2014Article
- Effects of the adenosine A2A antagonist istradefylline on cognitive performance in rats with a 6-OHDA lesion in prefrontal cortex.Psychopharmacology · 2013Article
- Executive dysfunction in Parkinson's disease and timing deficits.Frontiers in integrative neuroscience · 2013Review
- Prefrontal dopamine signaling and cognitive symptoms of Parkinson's disease.Reviews in the neurosciences · 2013Review
- Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The attentional set-shifting deficit that has been observed in Parkinson's disease (PD) has long been considered neuropsychological evidence of the involvement of meso-prefrontal and prefrontal-striatal circuits in cognitive flexibility. However, recent studies have suggested that non-dopaminergic, posterior cortical pathologies may also contribute to this deficit. Although several neuroimaging studies have addressed this issue, the results of these studies were confounded by the use of tasks that required other cognitive processes in addition to set-shifting, such as rule learning and working memory. In this study, we attempted to identify the neural correlates of the attentional set-shifting deficit in PD using a compound letter task and 18F-fluoro-deoxy-glucose (FDG) positron emission tomography during rest. Shift cost, which is a measure of attentional set-shifting ability, was significantly correlated with hypometabolism in the right dorsolateral prefrontal cortex, including the putative human frontal eye field. Our results provide direct evidence that dysfunction in the dorsolateral prefrontal cortex makes a primary contribution to the attentional set-shifting deficit that has been observed in PD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.