ArticlePLoS computational biology2012
Sarcomeric pattern formation by actin cluster coalescence.
Article in PLoS computational biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- An adapted particle swarm optimization algorithm as a model for exploring premyofibril formation.AIP advances · 2020Article
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- Exploring cardiac form and function: A length-scale computational biology approach.Wiley interdisciplinary reviews. Systems biology and medicine · 2020Review
- Remarkable structural transformations of actin bundles are driven by their initial polarity, motor activity, crosslinking, and filament treadmilling.PLoS computational biology · 2019Article
- Cofilin-1 phosphorylation catalyzed by ERK1/2 alters cardiac actin dynamics in dilated cardiomyopathy caused by lamin A/C gene mutation.Human molecular genetics · 2018Article
- Mechanical tension and spontaneous muscle twitching precede the formation of cross-striated muscleDevelopment (Cambridge, England) · 2017Article
- MEDYAN: Mechanochemical Simulations of Contraction and Polarity Alignment in Actomyosin Networks.PLoS computational biology · 2016Article
- A Combination of Actin Treadmilling and Cross-Linking Drives Contraction of Random Actomyosin Arrays.Biophysical journal · 2015Article
- Geometrical and mechanical properties control actin filament organization.PLoS computational biology · 2015Article
- Formation of contractile networks and fibers in the medial cell cortex through myosin-II turnover, contraction, and stress-stabilization.Cytoskeleton (Hoboken, N.J.) · 2015Article
- Heart-specific stiffening in early embryos parallels matrix and myosin expression to optimize beating.Current biology : CB · 2013Article
- Molecular mechanisms of cellular mechanosensing.Nature materials · 2013Article
- Mathematical modeling of eukaryotic cell migration: insights beyond experiments.Annual review of cell and developmental biology · 2013Review
- Alp/Enigma family proteins cooperate in Z-disc formation and myofibril assembly.PLoS genetics · 2013Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Contractile function of striated muscle cells depends crucially on the almost crystalline order of actin and myosin filaments in myofibrils, but the physical mechanisms that lead to myofibril assembly remains ill-defined. Passive diffusive sorting of actin filaments into sarcomeric order is kinetically impossible, suggesting a pivotal role of active processes in sarcomeric pattern formation. Using a one-dimensional computational model of an initially unstriated actin bundle, we show that actin filament treadmilling in the presence of processive plus-end crosslinking provides a simple and robust mechanism for the polarity sorting of actin filaments as well as for the correct localization of myosin filaments. We propose that the coalescence of crosslinked actin clusters could be key for sarcomeric pattern formation. In our simulations, sarcomere spacing is set by filament length prompting tight length control already at early stages of pattern formation. The proposed mechanism could be generic and apply both to premyofibrils and nascent myofibrils in developing muscle cells as well as possibly to striated stress-fibers in non-muscle cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.