ArticleJournal of bacteriology2012
First insights into the unexplored two-component system YehU/YehT in Escherichia coli.
Article in Journal of bacteriology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
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- Function and Regulation of the Pyruvate Transporter CstA inInternational journal of molecular sciences · 2020Article
- Importance of Pyruvate Sensing and Transport for the Resuscitation of Viable but NonculturableJournal of bacteriology · 2019Article
- Peptide Transporter CstA Imports Pyruvate in Escherichia coli K-12.Journal of bacteriology · 2018Article
- Review
- Evidence of Cross-Regulation in Two Closely Related Pyruvate-Sensing Systems in Uropathogenic Escherichia coli.The Journal of membrane biology · 2018Article
- BtsT, a Novel and Specific Pyruvate/HJournal of bacteriology · 2018Article
- A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance.Journal of bacteriology · 2018Article
- Identification of a High-Affinity Pyruvate Receptor in Escherichia coli.Scientific reports · 2017Article
- Review
- Comparative analysis of LytS/LytTR-type histidine kinase/response regulator systems in γ-proteobacteria.PloS one · 2017Article
- Insights into the DNA-binding mechanism of a LytTR-type transcription regulator.Bioscience reports · 2016Article
- Comparative genomics and experimental evolution of Escherichia coli BL21(DE3) strains reveal the landscape of toxicity escape from membrane protein overproduction.Scientific reports · 2015Article
- Genome-wide survey of two-component signal transduction systems in the plant growth-promoting bacterium Azospirillum.BMC genomics · 2015Article
- Dual-Color Monitoring Overcomes the Limitations of Single Bioluminescent Reporters in Fast-Growing Microbes and Reveals Phase-Dependent Protein Productivity during the Metabolic Rhythms of Saccharomyces cerevisiae.Applied and environmental microbiology · 2015Article
- Characterization of the E. coli proteome and its modifications during growth and ethanol stress.Frontiers in microbiology · 2015Article
- Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two-component systems (TCSs) consisting of a membrane-anchored histidine kinase (HK) and a response regulator (RR) with DNA-binding activity. are major players in signal transduction in prokaryotes. Whereas most TCSs in Escherichia coli are well characterized, almost nothing is known about the LytS-like HK YehU and the corresponding LytTR-like RR YehT. To identify YehT-regulated genes, we compared the transcriptomes of E. coli cells overproducing either YehT or the RR KdpE (control). The expression levels of 32 genes differed more than 8-fold between the two strains. A comprehensive evaluation of these genes identified yjiY as a target of YehT. Electrophoretic mobility shift assays with purified YehT confirmed that YehT interacts directly with the yjiY promoter. Specifically, YehT binds to two direct repeats of the motif ACC(G/A)CT(C/T)A separated by a 13-bp spacer in the yjiY promoter. The target gene yjiY encodes an inner membrane protein belonging to the CstA superfamily of transporters. In E. coli cells growing in media containing peptides or amino acids as a carbon source, yjiY is strongly induced at the onset of the stationary-growth phase. Moreover, expression was found to be dependent on cyclic AMP (cAMP)/cAMP receptor protein (CRP). It is suggested that YehU/YehT participates in the stationary-phase control network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.