ArticleThe Journal of comparative neurology2013
Distribution of vesicular glutamate transporter 2 (VGluT2) in the primary visual cortex of the macaque and human.
Article in The Journal of comparative neurology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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28 citing papers in PubMed, 42 citations in OpenAlex.
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- eLemur: A cellular-resolution 3D atlas of the mouse lemur brain.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Lamination, Borders, and Thalamic Projections of the Primary Visual Cortex in Human, Non-Human Primate, and Rodent Brains.Brain sciences · 2024Review
- Neuronal composition of processing modules in human V1: laminar density for neuronal and non-neuronal populations and a comparison with macaque.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Functional Connectivity Favors Aberrant Visual Network c-Fos Expression Accompanied by Cortical Synapse Loss in a Mouse Model of Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2024Article
- Dendritic Spines: Synaptogenesis and Synaptic Pruning for the Developmental Organization of Brain Circuits.Advances in neurobiology · 2023Article
- Cytochrome oxidase "blobs": a call for more anatomy.Brain structure & function · 2021Review
- APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease.Molecular psychiatry · 2021Article
- Comparative Ultrastructural Analysis of Thalamocortical Innervation of the Primary Motor Cortex and Supplementary Motor Area in Control and MPTP-Treated Parkinsonian Monkeys.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Layer-Specific Vesicular Glutamate Transporter 1 Immunofluorescence Levels Delineate All Layers of the Human Hippocampus Including theFrontiers in cellular neuroscience · 2021Article
- Immunoreactivity of Vesicular Glutamate Transporter 2 Corresponds to Cytochrome Oxidase-Rich Subcompartments in the Visual Cortex of Squirrel Monkeys.Frontiers in neuroanatomy · 2021Article
- The postnatal development of MT, V1, LGN, pulvinar and SC in prosimian galagos (Otolemur garnettii).The Journal of comparative neurology · 2020Article
- Functional Clusters of Neurons in Layer 6 of Macaque V1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Quantitative organization of the excitatory synapses of the primate cerebellar nuclei: further evidence for a specialized architecture underlying the primate cerebellum.Brain structure & function · 2019Article
- Densities and Laminar Distributions of Kv3.1b-, PV-, GABA-, and SMI-32-Immunoreactive Neurons in Macaque Area V1.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Major Feedforward Thalamic Input Into Layer 4C of Primary Visual Cortex in Primate.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Characterizing the optical properties of human brain tissue with high numerical aperture optical coherence tomography.Biomedical optics express · 2017Article
- Quantification of neuronal density across cortical depth using automated 3D analysis of confocal image stacks.Brain structure & function · 2017Article
- Ultrastructural analysis of parvalbumin synapses in human dorsolateral prefrontal cortex.The Journal of comparative neurology · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The majority of thalamic terminals in V1 arise from lateral geniculate nucleus (LGN) afferents. Thalamic afferent terminals are preferentially labeled by an isoform of the vesicular glutamate transporter, VGluT2. The goal of our study was to determine the distribution of VGluT2-ir puncta in macaque and human visual cortex. First, we investigated the distribution of VGluT2-ir puncta in all layers of macaque monkey primary visual cortex (V1), and found a very close correspondence between the known distribution of LGN afferents from previous studies and the distribution of VGluT2-immunoreactive (-ir) puncta. There was also a close correspondence between cytochrome oxidase density and VGluT2-ir puncta distribution. After validating the correspondence in macaque, we made a comparative study in human V1. In many aspects, the distribution of VGluT2-ir puncta in human was qualitatively similar to that of the macaque: high densities in layer 4C, patches of VGluT2-ir puncta in the supragranular layer (2/3), lower but clear distribution in layers 1 and 6, and very few puncta in layers 5 and 4B. However, there were also important differences between macaques and humans. In layer 4A of human, there was a sparse distribution of VGluT2-ir puncta, whereas in macaque, there was a dense distribution with the characteristic honeycomb organization. The results suggest important changes in the pattern of cortical VGluT2 immunostaining that may be related to evolutionary differences in the cortical organization of LGN afferents between Old World monkeys and humans.
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