SynthesisJournal of hospital medicine2012
Delirium in hospitalized patients: implications of current evidence on clinical practice and future avenues for research--a systematic evidence review.
Synthesis in Journal of hospital medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02345902 (Randomized Double-Blind Clinical Trial to Compare Haloperidol and Non-Pharmacologic Treatment Versus Non-Pharmacologic Treatment and Placebo, in Elderly Hospitalized Patients With Hypoactive Delirium), which is not on this map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Double-Blind Clinical Trial to Compare Haloperidol and Non-Pharmacologic Treatment Versus Non-Pharmacologic Treatment and Placebo, in Elderly Hospitalized Patients With Hypoactive Delirium
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 112 citations in OpenAlex.
- The Effects of Dexmedetomidine on Postoperative Delirium in Adult Cardiac Surgical Patients: A Bayesian Meta-Analysis and Trial Sequential Analysis.Acta anaesthesiologica Scandinavica · 2025Pooled it
- Acetylcholinesterase Inhibitors for Delirium in Older Adults.American journal of Alzheimer's disease and other dementias · 2016Pooled it
- Slow-Tempo Music and Delirium/Coma-Free Days Among Older Adults Undergoing Mechanical Ventilation: A Randomized Clinical Trial.JAMA internal medicine · 2025Trial
- Delirium severity does not differ between medical and surgical intensive care units after adjusting for medication use.Scientific reports · 2022Trial
- Association among rescue neuroleptic use, agitation, and perceived comfort: secondary analysis of a randomized clinical trial on agitated delirium.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Trial
- Deprescribing in the Pharmacologic Management of Delirium: A Randomized Trial in the Intensive Care Unit.Journal of the American Geriatrics Society · 2019Trial
- Preventing Postoperative Delirium After Major Noncardiac Thoracic Surgery-A Randomized Clinical Trial.Journal of the American Geriatrics Society · 2018Trial
- The descriptive epidemiology of delirium symptoms in a large population-based cohort study: results from the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS).BMC geriatrics · 2014Trial
- The Influence of Pharmacological Agents Used During General Anesthesia on the Intensity of Postoperative Pain and the Occurrence of Post-Anesthetic Delirium-A Scoping Review.Journal of clinical medicine · 2026Review
- [Factors-related to the severity of delirium among older adults in neurologic intensive care units: A retrospective study using electronic medical record data].Journal of Korean gerontological nursing · 2025Article
- Article
- Investigating the impact of fluid status on the ultrasound assessment of muscle quantity and quality in the diagnosis of sarcopenia - a multidimensional cross-sectional study.BMC geriatrics · 2023Article
- A summary of the current diagnostic methods for, and exploration of the value of microRNAs as biomarkers in, sepsis-associated encephalopathy.Frontiers in neuroscience · 2023Review
- Structured Delirium Management in the Hospital.Deutsches Arzteblatt international · 2022Article
- An Inpatient Geriatrics Program with a Focus on Any Type of Cognitive Impairment Reduces Mortality.The journal of nutrition, health & aging · 2022Article
- [82/m-Acute confusional state after falling out of bed : Preparation for the medical specialist examination: part 33].Der Internist · 2021Article
- Derivation and validation of a novel comorbidity-based delirium risk index to predict postoperative delirium using national administrative healthcare database.Health services research · 2021Article
- Approaches to Optimize Medication Data Analysis in Clinical Cohort Studies.Journal of the American Geriatrics Society · 2020Article
- In-hospital outcomes and 30-day readmission rates among ischemic and hemorrhagic stroke patients with delirium.PloS one · 2019Article
- Neurological Sequelae and Clinical Outcomes After Lung Transplantation.Transplantation direct · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundDespite the significant burden of delirium among hospitalized adults, critical appraisal of systematic data on delirium diagnosis, pathophysiology, treatment, prevention, and outcomes is lacking. PURPOSE: To provide evidence-based recommendations for delirium care to practitioners, and identify gaps in delirium research. DATA SOURCES: Medline, PubMed, the Cochrane Library, and the Cumulative Index to Nursing and Allied Health Literature (CINAHL) information systems from January 1966 to April 2011. STUDY SELECTION: All published systematic evidence reviews (SERs) on delirium were evaluated. DATA EXTRACTION: Three reviewers independently extracted the data regarding delirium risk factors, diagnosis, prevention, treatment, and outcomes, and critically appraised each SER as good, fair, or poor using the United States Preventive Services Task Force criteria. DATA SYNTHESIS: Twenty-two SERs graded as good or fair provided the data. Age, cognitive impairment, depression, anticholinergic drugs, and lorazepam use were associated with an increased risk for developing delirium. The Confusion Assessment Method (CAM) is reliable for delirium diagnosis outside of the intensive care unit. Multicomponent nonpharmacological interventions are effective in reducing delirium incidence in elderly medical patients. Low-dose haloperidol has similar efficacy as atypical antipsychotics for treating delirium. Delirium is associated with poor outcomes independent of age, severity of illness, or dementia.
conclusionDelirium is an acute, preventable medical condition with short- and long-term negative effects on a patient's cognitive and functional states.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.