Evidence map›Paper›PMID 22684680›Full record

ArticleAngewandte Chemie (International ed. in English)2012

Fluorochrome-functionalized magnetic nanoparticles for high-sensitivity monitoring of the polymerase chain reaction by magnetic resonance.

David Alcantara, Yanyan Guo, Hushan Yuan, Craig J Goergen, Howard H Chen, Hoonsung Cho, David E Sosnovik, Lee Josephson

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

David AlcantaraCenter for Translational Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, Charlestown, 02129, USA.
Yanyan Guo
Hushan Yuan
Craig J Goergen
Howard H Chen
Hoonsung Cho
David E Sosnovik
Lee Josephson

Funding

ULTRAHIGH FIELD TECHNOLOGY FOR FUNCTIONAL IMAGINGP41RR014075 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI ROSEN, BRUCE R · 1999 to 2011
$16.4M
Interdepartmental Neuroscience CenterP30NS045776 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BREAKEFIELD, XANDRA OWENS, TANNOUS, BAKHOS A · 2003 to 2018
$11.1M
Molecular and Microstructural Imaging of Cardiomyocyte Apoptosis and AutophagyR01HL093038 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SOSNOVIK, DAVID E · 2008 to 2012
$2.2M
Reagents for the Design of Targeted Multifunctional NanomaterialsR01EB009691 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI JOSEPHSON, LEE · 2009 to 2012
$1.5M
Multimodal Vital Fluorochromes for ImagingR01EB011996 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI JOSEPHSON, LEE · 2010 to 2013
$1.4M
Upgrade for Biospec Console and accessories for the 9.4T/20cm MagnetS10RR025563 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI DAI, GUANGPING · 2009 to 2009
$498k
NCRR NIH HHS P41 RR014075NCRR NIH HHS S10 RR025563NHLBI NIH HHS R01 HL093038NIBIB NIH HHS R01 EB009691NIBIB NIH HHS R01 EB011996NINDS NIH HHS P30 NS045776
6 · The paper itself

Abstract

Easy to find: magnetic nanoparticles bearing fluorochromes (red) that intercalate with DNA (green) form microaggregates with DNA generated by the polymerase chain reaction (PCR). These aggregates can be detected at low cycle numbers by magnetic resonance (MR).

Indexed as

Magnetic Resonance ImagingMagneticsPolymerase Chain ReactionApoptosisDNAFerrosoferric OxideFluorescenceFluorescent DyesHematinicsIntercalating AgentsNanoparticlesOrganic ChemicalsDNAFerrosoferric OxideFluorescent DyesHematinicsIntercalating AgentsOrganic ChemicalsTO-PRO-1

Identifiers

PMID22684680
PMCPMC3477829

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.