ArticleJournal of molecular neuroscience : MN2013
Upregulation of astrocytic leptin receptor in mice with experimental autoimmune encephalomyelitis.
Article in Journal of molecular neuroscience : MN, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Leptin as a Potential Modifier of Neuroinflammation: Contrasting Roles in Alzheimer's Disease and Multiple Sclerosis.International journal of molecular sciences · 2025Review
- Reproductive Dysfunction in Experimental Autoimmune Encephalomyelitis, an Animal Model of Multiple Sclerosis.Experimental neurobiology · 2025Article
- Hormones in experimental autoimmune encephalomyelitis (EAE) animal models.Translational neuroscience · 2021Review
- Leukocyte infiltration into spinal cord of EAE mice is attenuated by removal of endothelial leptin signaling.Brain, behavior, and immunity · 2014Article
- Leptin: a biomarker for sleep disorders?Sleep medicine reviews · 2014Article
- Bone morphogenetic protein 7 regulates reactive gliosis in retinal astrocytes and Müller glia.Molecular vision · 2014Article
- Leukocyte infiltration across the blood-spinal cord barrier is modulated by sleep fragmentation in mice with experimental autoimmune encephalomyelitis.Fluids and barriers of the CNS · 2014Article
- Loss of astrocytic leptin signaling worsens experimental autoimmune encephalomyelitis.Brain, behavior, and immunity · 2013Article
- Astrocytes differentially respond to inflammatory autoimmune insults and imbalances of neural activity.Acta neuropathologica communications · 2013Article
- Saturable leptin transport across the BBB persists in EAE mice.Journal of molecular neuroscience : MN · 2013Article
- Protective role of astrocytic leptin signaling against excitotoxicity.Journal of molecular neuroscience : MN · 2013Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The detrimental role of leptin in experimental autoimmune encephalomyelitis (EAE) is opposite to its neuroprotective role in other neuropathologies. We hypothesize that a shifted cellular distribution of leptin receptors underlies the differential effects of leptin. A robust increase of ObR immunoreactivity was seen along glial fibrillary acidic protein (GFAP)(+) intermediate filaments in reactive astrocytes in the hippocampus and hypothalamus of mice with EAE. Although astrocyte-specific GFAP mRNA and protein were both increased, ObRa mRNA was elevated only after resolution of EAE symptoms, and ObRb mRNA was even decreased at the peak time of symptoms of EAE. A cell type-specific action of leptin may underlie its differential effects.
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Registered trials
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