ArticleJournal of bone and mineral metabolism2012
Mean platelet volume is negatively associated with bone mineral density in postmenopausal women.
Article in Journal of bone and mineral metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Platelet Features and Derivatives in Osteoporosis: A Rational and Systematic Review on the Best Evidence.International journal of molecular sciences · 2020Pooled it
- Exploring the Association Between Platelet Count, the Systemic Immune Inflammation Index, and Fracture Risk in Postmenopausal Women with Osteoporosis: A Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Association of Mean Platelet Volume Expression with Bone Mineral Density in Patients with T2DM and CKD.International journal of general medicine · 2025Article
- The unexplored relationship between spontaneous osteoclastogenesis and platelets in osteoporosis.Frontiers in medicine · 2025Article
- Sex-specific association between platelet content and bone mineral density in adults: a cross-sectional study.BMC musculoskeletal disorders · 2024Article
- Identification of key genes and long non‑coding RNA expression profiles in osteoporosis with rheumatoid arthritis based on bioinformatics analysis.BMC musculoskeletal disorders · 2024Article
- Association between AXIN1 gene polymorphism (rs9921222) of WNT signaling pathway and susceptibility to osteoporosis in Egyptian patients: a case-control study.BMC musculoskeletal disorders · 2023Article
- Risk Factors Associated With Lower Bone Mineral Density in Primary Aldosteronism Patients.Frontiers in endocrinology · 2022Article
- Vitamin D and Platelets: A Menacing Duo in COVID-19 and Potential Relation to Bone Remodeling.International journal of molecular sciences · 2021Review
- Blood factors as biomarkers in osteoporosis: points from the COVID-19 era.Trends in endocrinology and metabolism: TEM · 2021Review
- High platelet count is associated with low bone mineral density: The MrOS Sweden cohort.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Article
- Clinical Features of 167 Inpatients with Autosomal Dominant Polycystic Kidney Disease at a Single Center in China.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Evaluation of bone mineral density (BMD) and indicators of bone turnover in patients with hemophilia.Bosnian journal of basic medical sciences · 2018Article
- Bone mineral density is associated with left ventricular diastolic function in women.Clinical cardiology · 2016Article
- Bone Mineral Density Is Negatively Associated With Arterial Stiffness in Men With Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Characterization and Risk Factor Analysis of Osteoporosis in a Large Cohort of Patients with Chronic Graft-versus-Host Disease.Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2016Article
- Association between mean platelet volume and bone mineral density in postmenopausal women.Journal of physical therapy science · 2016Article
- Is there a relationship between fracture healing and mean platelet volume?Therapeutics and clinical risk management · 2016Article
- Association between mean platelet volume and bone mineral density in patients with ankylosing spondylitis and diagnostic value of diffusion-weighted magnetic resonance imaging.Journal of physical therapy science · 2015Article
- Mean platelet volume and platelet distribution width can be related to bone mineralization.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis (OP) has been associated with cardiovascular disease. More specifically, osteoporosis was found to be an independent predictor of cardiovascular mortality. Recent studies revealed that platelets play a critical role in bone remodeling. Mean platelet volume (MPV) is an early marker of platelet activation, which is involved in the pathophysiology of coronary heart disease. However, little research has been conducted to investigate the relationship between MPV and OP. In this cross-sectional study, we investigated the relationship between platelet count, MPV, and bone mineral density (BMD) in 410 subjects in the geriatric department of the Second Affiliated Hospital, Harbin, China. Different biochemical parameters, platelet count, and MPV were determined, and bone mineral density (BMD) (g/cm(2)) was measured in the osteoporosis, osteopenia, and normal BMD groups. Mean age, systolic blood pressure (SBP), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), and MPV increased gradually, and body mass index (BMI), decreased as BMD decreased. A negative correlation was present between MPV and the lumbar spine (L2-L4) and femoral neck BMD after adjusting other risk factors. Univariate analysis and multivariate analysis showed that MPV was significantly associated with lumbar spine L2-L4 BMD and femoral neck BMD (β = -0.285, P < 0.001 for lumbar spine L2-L4 BMD; β = -0.207, P < 0.001 for femoral neck BMD in multivariate model). The findings show that MPV is negatively correlated with BMD. Further studies on the involvement of MPV in osteoporosis may contribute to the evaluation of thrombotic risk in elderly patients with osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.