ArticleEuropean journal of immunology2012
Silencing of the Il2 gene transcription is regulated by epigenetic changes in anergic T cells.
Article in European journal of immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
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- Towards precision medicine for systemic lupus erythematosus and neuropsychiatric manifestations.Expert review of precision medicine and drug development · 2025Article
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- Expression of leukotriene BCellular & molecular immunology · 2021Article
- Established and emergent roles for Ikaros transcription factors in lymphoid cell development and function.Immunological reviews · 2021Review
- Role of Aiolos and Ikaros in the Antitumor and Immunomodulatory Activity of IMiDs in Multiple Myeloma: Better to Lose Than to Find Them.International journal of molecular sciences · 2021Review
- The epigenetic regulator ATF7ip inhibitsThe Journal of experimental medicine · 2019Article
- Long-Range Transcriptional Control of the Il2 Gene by an Intergenic Enhancer.Molecular and cellular biology · 2015Article
- The Regulatory T Cell Lineage Factor Foxp3 Regulates Gene Expression through Several Distinct Mechanisms Mostly Independent of Direct DNA Binding.PLoS genetics · 2015Article
- Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms.EMBO reports · 2014Article
- Tle4 regulates epigenetic silencing of gamma interferon expression during effector T helper cell tolerance.Molecular and cellular biology · 2014Article
- Induction and stability of the anergic phenotype in T cells.Seminars in immunology · 2013Review
- Kruppel-associated box (KRAB) proteins in the adaptive immune system.Nucleus (Austin, Tex.)Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Anergy is induced in T cells as a consequence of a partial or suboptimal stimulation. Anergic T cells become unresponsive and fail to proliferate and produce cytokines. We had previously shown that in anergic CD4(+) T cells, Ikaros participates in the transcriptional repression of the Il2 gene by recruiting histone deacetylases that cause core histone deacetylation at the Il2 promoter. Here we show that deacetylation at the Il2 promoter is the initial step in a process that leads to the stable silencing of the Il2 gene transcription in anergic T cells. We have found that anergy-induced deacetylation of the Il2 promoter permits binding of the histone methyl-transferase Suv39H1, which trimethylates lysine-9 of histone H3 (Me3H3-K9). Furthermore, the establishment of the Me3H3-K9 mark allows the recruitment of the heterochromatin protein HP1, allowing the silenced Il2 loci to reposition close to heterochromatin-rich regions. Our results indicate that silencing of Il2 transcription in anergic T cells is attained through a series of epigenetic changes that involve the establishment of repressive marks and the subsequent nuclear repositioning of the Il2 loci, which become juxtaposed to transcriptionally silent regions. This mechanism may account for the stable nature of the inhibition of IL-2 production in anergic cells.
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