Evidence map›Paper›PMID 22684505›Full record

ArticleNucleic acids research2012

IMP: a multi-species functional genomics portal for integration, visualization and prediction of protein functions and networks.

Aaron K Wong, Christopher Y Park, Casey S Greene, Lars A Bongo, Yuanfang Guan, Olga G Troyanskaya

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
8.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 137 citations in OpenAlex.

  1. CD74 is a functional MIF receptor on activated CD4Cellular and molecular life sciences : CMLS · 2024
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  5. Brain Imaging Genomics: Integrated Analysis and Machine Learning.Proceedings of the IEEE. Institute of Electrical and Electronics Engineers · 2020
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  8. NewG3 (Bethesda, Md.) · 2019
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  12. Machine Learning Analysis IdentifiesG3 (Bethesda, Md.) · 2017
    Article
  13. Article
  14. Article
  15. Article
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  17. Article
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  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Aaron K WongDepartment of Computer Science, Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA.
Christopher Y Park
Casey S Greene
Lars A Bongo
Yuanfang Guan
Olga G Troyanskaya
University of Michigan–Ann Arbor · USAnn Arbor Center for Independent Living · USPrinceton University · US

Funding

Spatial Patterning During DevelopmentP50GM071508 · NIGMS · PRINCETON UNIVERSITY · PI POWELL, SUSAN M · 2004 to 2013
$30.6M
Quantitavie and Computational Biology Graduate ProgramT32HG003284 · NHGRI · PRINCETON UNIVERSITY · PI Joshua Michael Akey, Stanislav Y. Shvartsman · 2004 to 2026
$9.9M
lntegration and Visualization of Diverse Biological DataR01GM071966 · NIGMS · PRINCETON UNIVERSITY · PI TROYANSKAYA, OLGA G · 2005 to 2022
$6.4M
Systematic data curation and integration to link models of human diseaseR24OD011194 · OD · PRINCETON UNIVERSITY · PI DOLINSKI, KARA · 2012 to 2014
$1.9M
Context-Sensitive Search of Human Expression CompendiaR01HG005998 · NHGRI · PRINCETON UNIVERSITY · PI TROYANSKAYA, OLGA G · 2011 to 2013
$1.1M
Systematic data curation and integration to link models of human diseaseR24RR032659 · NCRR · PRINCETON UNIVERSITY · PI DOLINSKI, KARA · 2011 to 2011
$675k
NCRR NIH HHS R24 RR032659NHGRI NIH HHS R01 HG005998NHGRI NIH HHS T32 HG003284NIGMS NIH HHS P50 GM071508NIGMS NIH HHS R01 GM071966NIH HHS R24 OD011194
6 · The paper itself

Abstract

Integrative multi-species prediction (IMP) is an interactive web server that enables molecular biologists to interpret experimental results and to generate hypotheses in the context of a large cross-organism compendium of functional predictions and networks. The system provides a framework for biologists to analyze their candidate gene sets in the context of functional networks, as they expand or focus these sets by mining functional relationships predicted from integrated high-throughput data. IMP integrates prior knowledge and data collections from multiple organisms in its analyses. Through flexible and interactive visualizations, researchers can compare functional contexts and interpret the behavior of their gene sets across organisms. Additionally, IMP identifies homologs with conserved functional roles for knowledge transfer, allowing for accurate function predictions even for biological processes that have very few experimental annotations in a given organism. IMP currently supports seven organisms (Homo sapiens, Mus musculus, Rattus novegicus, Drosophila melanogaster, Danio rerio, Caenorhabditis elegans and Saccharomyces cerevisiae), does not require any registration or installation and is freely available for use at http://imp.princeton.edu.

Indexed as

Gene Regulatory NetworksSoftwareAnimalsComputer GraphicsGenesGenomicsHumansInternetMiceProteinsRatsRepressor ProteinsSystems IntegrationZebrafish ProteinsEve1 protein, zebrafishProteinsRepressor ProteinsZebrafish Proteins

Identifiers

PMID22684505
PMCPMC3394282
OpenAlexW2052968292

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.