Evidence map›Paper›PMID 22684454›Full record

ArticleCancer discovery2012

Tracking evolution of BRCA1-associated breast cancer.

Jos Jonkers

Abstract readComment
PubMed Publisher
In one paragraph

Article in Cancer discovery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The Role of Ubiquitination and SUMOylation in Telomere Biology.Current issues in molecular biology · 2020
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Jos JonkersDivision of Molecular Pathology, The Netherlands Cancer Institute, Amsterdam, The Netherlands. j.jonkers@nki.nl

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Single-cell profiling and computational identification of evolutionary paths to BRCA1-associated tumorigenesis predict that PTEN loss and TP53 mutation precede loss of wild-type BRCA1 in basal-like and luminal tumors, respectively.

Indexed as

BRCA1 ProteinBreast NeoplasmsFemaleHumansPTEN PhosphohydrolaseTumor Suppressor Protein p53BRCA1 ProteinBRCA1 protein, humanPTEN PhosphohydrolasePTEN protein, humanTP53 protein, humanTumor Suppressor Protein p53

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.