Evidence map›Paper›PMID 22684340›Full record

ReviewHeart failure reviews2013

Unraveling new mechanisms of exercise intolerance in chronic heart failure: role of exercise training.

Viviane M Conraads, Emeline M Van Craenenbroeck, Catherine De Maeyer, An M Van Berendoncks, Paul J Beckers, Christiaan J Vrints

Registry-linked trialAbstract readComparative StudyReview
PubMed Publisher
In one paragraph

Review in Heart failure reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02508792 (Acute Effects of Low Level Laser Therapy in Muscle Function of Patients With Heart Failure.), which is not on this map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
16.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02508792 naunknown statusnot on this mapstarted 2015, after this paper: background citation

Acute Effects of Low Level Laser Therapy in Muscle Function of Patients With Heart Failure.

TypeinterventionalSponsorFederal University of Health Science of Porto AlegreRan2015Enrolled20ConditionsHeart FailureArmsLASER, LASER PLACEBO
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  12. [Cardiac rehabilitation in heart failure].Wiener medizinische Wochenschrift (1946) · 2018
    Review
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  15. Myocardial Expression of PPARPPAR research · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Viviane M ConraadsDepartment of Cardiology, Antwerp University Hospital, Edegem, Belgium. Viviane.Conraads@uza.be
Emeline M Van Craenenbroeck
Catherine De Maeyer
An M Van Berendoncks
Paul J Beckers
Christiaan J Vrints
Antwerp University Hospital · BEUniversity of Antwerp · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite remarkable progress in the therapeutic approach of patients with chronic heart failure (CHF), exercise intolerance remains one of the hallmarks of the disease. During the past two decades, evidence has accumulated to underscore the key role of both endothelial dysfunction and skeletal muscle wasting in the process that gradually leads to physical incapacity. Whereas reverse ventricular remodeling has been attributed to aerobic exercise training, the vast majority of studies conducted in this specific patient population emphasize the reversal of peripheral abnormalities. In this review, we provide a general overview on underlying pathophysiological mechanisms. In addition, emphasis is put on recently identified pathways, which contribute to a deeper understanding of the main causes of exercise tolerance and the potential for reversal through exercise training. Recently, deficient bone marrow-related endothelial repair mechanisms have received considerable attention. Both acute exercise bouts, as well as exercise training, affect the mobilization of endothelial progenitor cells and their function. The observed changes following exercise training are believed to significantly contribute to improvement of peripheral endothelial function, as well as exercise capacity. With regard to skeletal muscle dysfunction and energy deprivation, adiponectin has been suggested to play a significant role. The demonstration of local skeletal muscle adiponectin resistance may provide an interesting and new link between the insulin resistant state and skeletal muscle wasting in CHF patients.

Indexed as

AdultAgedChronic DiseaseEndothelium, VascularEvidence-Based MedicineExerciseExercise TherapyExercise ToleranceFemaleHeart FailureHumansMaleMiddle AgedMuscle WeaknessPrognosisRisk Assessment

Identifiers

PMID22684340
OpenAlexW2052803849

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.