ArticleSocial psychiatry and psychiatric epidemiology2013
Stress and development of depression and heavy drinking in adulthood: moderating effects of childhood trauma.
Article in Social psychiatry and psychiatric epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Understanding the interplay of social context and physiology on psychological outcomes in trauma-exposed adolescents: a protocol and baseline data report.European journal of psychotraumatology · 2026Article
- Association between Adverse Childhood Experiences and Binge Drinking among Adults: The Moderating Effect of Race/Ethnicity.Journal of racial and ethnic health disparities · 2026Article
- Sex and Stress Govern the Function and Innervation of a Basolateral Amygdala to Nucleus Accumbens Corticotropin-Releasing Hormone/GABA-Expressing Projection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Dysregulated responses to stress and alcohol cues in cortico-striatal-limbic regions in social drinkers with early trauma.Journal of neural transmission (Vienna, Austria : 1996) · 2025Article
- Adolescent resilience in the face of COVID-19 stressors: the role of trauma and protective factors.Psychological medicine · 2024Article
- LPS-induced whole-blood cytokine production and depressive symptoms in dementia spousal caregivers: The moderating effect of childhood trauma.Psychoneuroendocrinology · 2024Article
- After Hurricane Maria: Effects of disaster trauma on Puerto Rican survivors on the U.S. mainland.Psychological trauma : theory, research, practice and policy · 2024Article
- Individual Differences in Substance Use Motives, Trauma, and Stress Among College-Based Polysubstance Users.Substance use & misuse · 2024Article
- Article
- Sex-specific behavioral outcomes of early-life adversity and emerging microglia-dependent mechanisms.Frontiers in behavioral neuroscience · 2022Article
- The disparate impact of COVID-19 on the mental health of female and male caregivers.Social science & medicine (1982) · 2021Article
- Getting to Know the Inner Self. Exploratory Study of Identity Oriented Psychotrauma Therapy-Experiences and Value From Multiple Perspectives.Frontiers in psychiatry · 2021Article
- Clinical Correlates of Alcohol Use Disorder in Depressed Patients with Unipolar and Bipolar Disorder.Psychiatry investigation · 2019Article
- Childhood Adversities and Physical and Mental Health Outcomes in Adults Living with HIV: Findings from the Ontario HIV Treatment Network Cohort Study.AIDS research and treatment · 2018Article
- A qualitative analysis of parental loss and family separation among youth in post-conflict Liberia.Vulnerable children and youth studies · 2017Article
- Child abuse and the prevalence of suicide attempts among those reporting suicide ideation.Social psychiatry and psychiatric epidemiology · 2016Article
- Childhood adversity and subsequent mental health status in adulthood: screening for associations using two linked surveys.Epidemiology and psychiatric sciences · 2016Review
- Retrospective and prospectively assessed childhood adversity in association with major depression, alcohol consumption and painful conditions.Epidemiology and psychiatric sciences · 2015Article
- Stress modulates illness-course of substance use disorders: a translational review.Frontiers in psychiatry · 2014Review
- Childhood trauma, personality disorders symptoms and current major depressive disorder in Togo.Social psychiatry and psychiatric epidemiology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeStudies suggest that childhood trauma is linked to both depression and heavy drinking in adulthood, and may create a lifelong vulnerability to stress. Few studies have explored the effects of stress sensitization on the development of depression or heavy drinking among those who have experienced traumatic childhood events. This study aimed to determine the effect of childhood trauma on the odds of experiencing depression or heavy drinking in the face of an adult life stressor, using a large population-based Canadian cohort.
methodsA total of 3,930 participants were included from the National Population Health Survey. The associations among childhood trauma, recent stress and depression/heavy drinking from 1994/1995 to 2008/2009 were explored using logistic regression, as were interactions between childhood trauma and recent stress. A generalized linear mixed model was used to determine the effects of childhood trauma and stressful events on depression/heavy drinking. Analyses were stratified by sex.
resultsChildhood trauma significantly increased the odds of becoming depressed (following 1 event: OR = 1.66; 95%CI 1.01, 2.71; 2+ events, OR = 3.89; 95%CI 2.44, 6.22) and drinking heavily (2+ events: OR = 1.79; 95%CI 1.03, 3.13). Recent stressful events were associated with depression, but not heavy drinking. While most interaction terms were not significant, in 2004/2005 the association between recent stress and depression was stronger in those who reported childhood trauma compared to those with no childhood trauma.
conclusionsChildhood trauma increases risk for both depression and heavy drinking. Trauma may moderate the effect of stress on depression; the relationship among trauma, stress and heavy drinking is less clear.
Indexed as
Identifiers
22684339What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.