ArticleDiabetologia2012
No evidence of enteroviruses in the intestine of patients with type 1 diabetes.
Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Association between enterovirus infection and clinical type 1 diabetes mellitus: systematic review and meta-analysis of observational studies.Epidemiology and infection · 2021Pooled it
- Ensemble Deep Learning Models on Raw DNA Sequences for Viral Genome Identification in Human Samples.Sensors (Basel, Switzerland) · 2026Article
- Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes.Diabetologia · 2025Article
- The perfect storm: unraveling the interplay of genetic predisposition and viral triggers in type 1 diabetes pathogenesis.Frontiers in endocrinology · 2025Review
- Detection of enterovirus RNA in pancreas and lymphoid tissues of organ donors with type 1 diabetes.medRxiv : the preprint server for health sciences · 2024Article
- Persistent coxsackievirus B infection and pathogenesis of type 1 diabetes mellitus.Nature reviews. Endocrinology · 2022Review
- Immunohistochemical detection of enteroviruses in pancreatic tissues of patients with type 1 diabetes using a polyclonal antibody against 2A protease of Coxsackievirus.Journal of diabetes investigation · 2022Article
- Genetic and Environmental Interaction in Type 1 Diabetes: a Relationship Between Genetic Risk Alleles and Molecular Traits of Enterovirus Infection?Current diabetes reports · 2019Review
- Enterovirus as trigger of coeliac disease: nested case-control study within prospective birth cohort.BMJ (Clinical research ed.) · 2019Article
- ViraMiner: Deep learning on raw DNA sequences for identifying viral genomes in human samples.PloS one · 2019Article
- Enteroviral Infections as a Trigger for Type 1 Diabetes.Current diabetes reports · 2018Review
- Article
- A new monoclonal antibody (Cox mAB 31A2) detects VP1 protein of coxsackievirus B3 with high sensitivity and specificity.Virchows Archiv : an international journal of pathology · 2016Article
- The role for gut permeability in the pathogenesis of type 1 diabetes--a solid or leaky concept?Pediatric diabetes · 2015Review
- Lessons from the mouse: potential contribution of bystander lymphocyte activation by viruses to human type 1 diabetes.Diabetologia · 2015Review
- Luminex and other multiplex high throughput technologies for the identification of, and host response to, environmental triggers of type 1 diabetes.BioMed research international · 2015Review
- Potential viral pathogenic mechanism in human type 1 diabetes.Diabetologia · 2014Review
- Next-generation sequencing for viruses in children with rapid-onset type 1 diabetes.Diabetologia · 2013Article
- Previous maternal infection protects offspring from enterovirus infection and prevents experimental diabetes development in mice.Diabetologia · 2013Article
- In type 1 diabetes a subset of anti-coxsackievirus B4 antibodies recognize autoantigens and induce apoptosis of pancreatic beta cells.PloS one · 2013Article
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aims/hypothesisThe purpose of this study was to investigate whether the gut mucosa is a reservoir for enterovirus persistence in patients with type 1 diabetes.
methodsSmall intestine biopsy samples from 25 individuals at different stages of type 1 diabetes, 21 control individuals and 27 individuals with coeliac disease were analysed for the presence of enterovirus RNA by using both radioactive in-situ hybridisation and real-time RT-PCR and for the presence of enterovirus proteins by immunostaining with antibodies against VP1 and VP4-2-3 capsid proteins and virus polymerase. Lymphocytic enteropathy and serum anti-VP1 antibodies were also evaluated at the time of biopsy. Moreover, high-throughput sequencing was performed to identify viral transcripts or genomes.
resultsEnterovirus was not detected by in-situ hybridisation or RT-PCR in any of the individuals tested. Immunohistology revealed a few stained cells in the intestinal epithelium in a low number of individuals, with no difference between diabetic and non-diabetic individuals. Levels of serum IgG against VP1 did not differ between control individuals and those with diabetes or coeliac disease and no evidence of diabetes-related lymphocytic enteropathy was detected. High-throughput sequencing did not reveal specific enterovirus sequences in the gut mucosa of individuals with type 1 diabetes. CONCLUSIONS/
interpretationProlonged/persistent enterovirus infections in gut mucosa are not common in patients with type 1 diabetes.
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