ArticleArchives of disease in childhood. Fetal and neonatal edition2013
Spontaneous intestinal perforation in extremely low birth weight infants: association with indometacin therapy and effects on neurodevelopmental outcomes at 18-22 months corrected age.
Article in Archives of disease in childhood. Fetal and neonatal edition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 58 citations in OpenAlex.
- Use of NSAIDs and acetaminophen and risk of spontaneous intestinal perforations in premature infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Role of Nutrition in Prevention of Neonatal Spontaneous Intestinal Perforation and Its Complications: A Systematic Review.Nutrients · 2020Pooled it
- Lipid enemas for meconium evacuation in preterm infants - a retrospective cohort study.BMC pediatrics · 2021Trial
- A randomized trial of intravenous acetaminophen versus indomethacin for treatment of hemodynamically significant PDAs in VLBW infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Trial
- Nutrition of the preterm infant with persistent ductus arteriosus: existing evidence and practical implications.Pediatric research · 2026Review
- Nutritional Management for Preterm Infants with Common Comorbidities: A Narrative Review.Nutrients · 2025Review
- The Association Between Perinatal Pharmacologic Treatments and Spontaneous Intestinal Perforation in Extremely Preterm Infants: A Propensity Score Matching Study.Children (Basel, Switzerland) · 2025Article
- Spontaneous intestinal perforation among very preterm infants in China: a multicenter cohort study.Translational pediatrics · 2024Article
- Association of Intrapartum Drugs with Spontaneous Intestinal Perforation: A Single-Center Retrospective Review.American journal of perinatology · 2024Review
- Prophylactic indomethacin, antenatal betamethasone, and the risk of intestinal perforation in infants <28 weeks' gestation.Journal of perinatology : official journal of the California Perinatal Association · 2023Observational
- Antenatal Steroids, Prophylactic Indomethacin, and the Risk of Spontaneous Intestinal Perforation.The Journal of pediatrics · 2023Article
- Patent ductus arteriosus and spontaneous intestinal perforation in a cohort of preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Spontaneous intestinal perforation in premature infants: a national study.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Patent Ductus Arteriosus of the Preterm Infant.Pediatrics · 2020Review
- Review
- Complications associated with the current sequential pharmacological management of early postnatal hypotension in extremely premature infants.Proceedings (Baylor University. Medical Center) · 2019Article
- Less invasive surfactant administration and complications of preterm birth.Scientific reports · 2018Article
- Management of neonatal spontaneous intestinal perforation by peritoneal needle aspiration.Journal of perinatology : official journal of the California Perinatal Association · 2018Article
- Effect of prophylactic indomethacin administration and early feeding on spontaneous intestinal perforation in extremely low-birth-weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Pharmacological Closure of Patent Ductus Arteriosus: Selecting the Agent and Route of Administration.Paediatric drugs · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundSpontaneous intestinal perforation (SIP) is associated with the use of postnatal glucocorticoids and indometacin in extremely low birth weight (ELBW) infants. The authors hypothesised: 1) an association of SIP with the use of antenatal steroids (ANS) and indometacin either as prophylaxis for intraventricular hemorrhage (IVH) (P Indo) or for treatment of PDA (Indo/PDA) and 2) an increased risk of death or abnormal neurodevelopmental outcomes in infants with SIP at 18-22 months corrected age. DESIGN/
methodsThe authors retrospectively identified ELBW infants with SIP in the Neonatal Research Network's generic database. Unadjusted analysis identified the differences in maternal, neonatal and clinical variables between infants with and without SIP. Logistic regression analysis identified the adjusted OR for SIP with reference to ANS, P Indo and Indo/PDA. Neurodevelopmental outcomes were assessed among survivors at 18-22 months corrected age.
resultsIndo/PDA was associated with an increased risk of SIP (adjusted OR 1.61; 95% CI 1.25 to 2.08), while P Indo and ANS were not. SIP was independently associated with an increased risk of death or neurodevelopmental impairment (NDI) (adjusted OR 1.85; 95% CI 1.32 to 2.60) and NDI among survivors (adjusted OR 1.75, 95% CI 1.20 to 2.55).
conclusionIndometacin used for IVH prophylaxis and ANS were not associated with the occurrence of SIP in ELBW infants. Indometacin used for treatment of symptomatic PDA was however associated with an increased risk of SIP. ELBW infants with SIP have an increased risk of poor neurodevelopmental outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.