ArticleEuropean journal of pharmacology2012
Comparison of TRPA1-versus TRPV1-mediated cough in guinea pigs.
Article in European journal of pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 64 citations in OpenAlex.
- Heterogeneity of cough hypersensitivity mediated by TRPV1 and TRPA1 in patients with chronic refractory cough.Respiratory research · 2019Trial
- Where Eastern Medicine Meets Western Medicine: A World Review of the Management of Chronic Cough.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Physiological mechanisms and therapeutic targets in chronic cough.Physiological reports · 2026Review
- Wired for immunity: neuroimmune control of the lung by sensory neurons.Nature reviews. Neuroscience · 2026Review
- Reflex regulation of respiration and heart rate by inhaled activators of vagal bronchopulmonary afferents.Journal of neurophysiology · 2025Article
- Infectious and Inflammatory Pathways to Cough.Annual review of physiology · 2023Review
- Review
- Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker.British journal of pharmacology · 2021Article
- Thermosensory Transient Receptor Potential Ion Channels and Asthma.Biomedicines · 2021Review
- Differential sensitivity of cinnamaldehyde-evoked calcium fluxes to ruthenium red in guinea pig and mouse trigeminal sensory neurons.BMC research notes · 2021Article
- TRP channels in airway sensory nerves.Neuroscience letters · 2021Review
- Molecular identity, anatomy, gene expression and function of neural crest vs. placode-derived nociceptors in the lower airways.Neuroscience letters · 2021Review
- Methods for assessing cough sensitivity.Journal of thoracic disease · 2020Review
- Transient receptor potential ankyrin-1 causes rapid bronchodilation via nonepithelial PGEAmerican journal of physiology. Lung cellular and molecular physiology · 2020Article
- Analysis of TRPA1 antagonist, A-967079, in plasma using high-performance liquid chromatography tandem mass-spectrometry.Journal of pharmaceutical analysis · 2020Article
- The Prospect for Potent Sodium Voltage-Gated Channel Blockers to Relieve an Excessive Cough.Physiological research · 2020Review
- Female Guinea Pig Model for Cough Studies and Its Response to Most Common Tussive Substances.Physiological research · 2020Article
- Upper Airway Cough Syndrome in Pathogenesis of Chronic Cough.Physiological research · 2020Review
- The voltage-gated sodium channel NaRespiratory physiology & neurobiology · 2019Article
- Nociceptive pulmonary-cardiac reflexes are altered in the spontaneously hypertensive rat.The Journal of physiology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
TRPA1 receptor is activated by endogenous inflammatory mediators and exogenous pollutant molecules relevant to respiratory diseases. Previous studies have implicated TRPA1 as a drug target for antitussive therapy. Here we evaluated the relative efficacy of TRPA1 activation to evoke cough. In conscious guinea pigs the TRPA1 agonist allyl-isothiocyanate (AITC) evoked cough with a maximally effective concentration of 10mM that was abolished by the selective TRPA1 antagonist AP-18. AITC (10mM) was approximately 3-times less effective in inducing cough than capsaicin (50 μM). Ex vivo single fiber extracellular recordings revealed that, similarly to capsaicin, AITC evoked activation in airway jugular C-fibers, but not in airway nodose Aδ-fibers. Consistent with the cough studies, AITC was approximately 3-times less effective than capsaicin in evoking sustained activation of the jugular C-fibers. Another TRPA1 agonist, cinnamaldehyde, was approximately twofold more effective than AITC in inducing cough. However, the cinnamaldehyde (10mM)-induced cough was only partially inhibited by the TRPA1 antagonist AP-18, and was abolished by combination of AP-18 and the TRPV1 antagonist I-RTX. We conclude that in naïve guinea pigs, TRPA1 activation initiates cough that is relatively modest compared to the cough initiated by TRPV1, likely due to lower efficacy of TRPA1 stimulation to induce sustained activation of airway C-fibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.