ArticleDevelopmental biology2012
ADAM13 function is required in the 3 dimensional context of the embryo during cranial neural crest cell migration in Xenopus laevis.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- ADAM19: biological characteristics and implications in disease pathology and clinical applications.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Adam13 interacts with large protein complexes to regulate histone modification and gene expression.Frontiers in cell and developmental biology · 2026Article
- Bop1 is required to establish precursor domains of craniofacial tissues.Genesis (New York, N.Y. : 2000) · 2024Article
- ADAM11 a novel regulator of Wnt and BMP4 signaling in neural crest and cancer.Frontiers in cell and developmental biology · 2023Article
- Zmym4 is required for early cranial gene expression and craniofacial cartilage formation.Frontiers in cell and developmental biology · 2023Article
- Mcrs1 is required for branchial arch and cranial cartilage development.Developmental biology · 2022Article
- The road best traveled: Neural crest migration upon the extracellular matrix.Seminars in cell & developmental biology · 2020Review
- Functions of 'A disintegrin and metalloproteases (ADAMs)' in the mammalian nervous system.Cellular and molecular life sciences : CMLS · 2019Review
- Cellular organization and boundary formation in craniofacial development.Genesis (New York, N.Y. : 2000) · 2019Review
- Cut loose and run: The complex role of ADAM proteases during neural crest cell development.Genesis (New York, N.Y. : 2000) · 2018Review
- Cranial Neural Crest Transplants.Cold Spring Harbor protocols · 2018Article
- Cranial Neural Crest Explants.Cold Spring Harbor protocols · 2018Article
- Article
- Should I stay or should I go? Cadherin function and regulation in the neural crest.Genesis (New York, N.Y. : 2000) · 2017Review
- ADAM13 cleavage of cadherin-11 promotes CNC migration independently of the homophilic binding site.Developmental biology · 2016Article
- The Wnt receptor Frizzled-4 modulates ADAM13 metalloprotease activity.Journal of cell science · 2015Article
- Neural crest migration: trailblazing ahead.F1000prime reports · 2015Review
- GSK3 and Polo-like kinase regulate ADAM13 function during cranial neural crest cell migration.Molecular biology of the cell · 2014Article
- A nonsynonymous mutation in the transcriptional regulator lbh is associated with cichlid craniofacial adaptation and neural crest cell development.Molecular biology and evolution · 2014Article
- Negative feedback regulation of Wnt signaling via N-linked fucosylation in zebrafish.Developmental biology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The cranial neural crest (CNC) is a population of cells that arises from the lateral part of the developing brain, migrates ventrally and coordinates the entire craniofacial development of vertebrates. Many molecules are involved in CNC migration including the transmembrane metalloproteases ADAM13 and 19. We have previously shown that these ADAMs cleave a number of extracellular proteins and modify the transcription of a number of genes, and that both of these activities are important for cell migration. Here we show that the knock down of ADAM13 inhibits CNC migration in vivo but not in vitro, indicating that ADAM13 function is required in the 3-dimentional context of the embryo. We further show that the migration of CNC that do not express ADAM13 and ADAM19 can be rescued in vivo by co-grafting wild type CNC. Furthermore, the migration of CNC lacking ADAM13 can be rescued by mechanically separating the CNC from the surrounding ectoderm and mesoderm. Finally, we show that ADAM13 function is autonomous to CNC tissue, as the migration of morphant CNC can only be rescued by ADAM13 expression in the CNC and not the surrounding tissues. Together our results suggest that ADAM13 changes CNC interaction with the extracellular environment and that this change is necessary for their migration in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.