ReviewClinica chimica acta; international journal of clinical chemistry2012
Urinary biomarkers of oxidative status.
Review in Clinica chimica acta; international journal of clinical chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
127 citing papers in PubMed, 1 synthesis or guideline pooled it, 245 citations in OpenAlex.
- Effect of Running Exercise on Oxidative Stress Biomarkers: A Systematic Review.Frontiers in physiology · 2020Pooled it
- The Effects of Black Raspberry as a Whole Food-Based Approach on Biomarkers of Oxidative Stress in Buccal Cells and Urine of Smokers.Cancer prevention research (Philadelphia, Pa.) · 2024Trial
- The effect of liraglutide and sitagliptin on oxidative stress in persons with type 2 diabetes.Scientific reports · 2021Trial
- Effects of 2 years of caloric restriction on oxidative status assessed by urinary F2-isoprostanes: The CALERIE 2 randomized clinical trial.Aging cell · 2018Trial
- Trial
- Oxidative Stress Assessment in Response to Ultraendurance Exercise: Thiols Redox Status and ROS Production according to Duration of a Competitive Race.Oxidative medicine and cellular longevity · 2016Trial
- A liquid chromatography- tandem mass spectrometry method for the analysis of oxidative stress, nitrative stress, metabolic, and inflammatory biomarkers in serum: comparison to urinary concentrations.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2026Article
- Exploring urinary allantoin and adenosine in pediatric autosomal dominant polycystic kidney disease: no clear association with disease severity.Pediatric nephrology (Berlin, Germany) · 2026Observational
- Urinary TBARS as a Non-Invasive Proxy of Plasma Lipid Peroxidation in Essential Hypertension: A Translational Study on Vascular Oxidative-Inflammatory Burden.Antioxidants (Basel, Switzerland) · 2026Article
- Tuning the Fire: Context-Dependent Mitochondrial ROS Signaling, Mitohormesis, and Redox-Modulating Interventions.Biomolecules · 2026Review
- Oxidative stress and fetal weight: observational findings from a pregnancy cohort in New York City.Journal of perinatology : official journal of the California Perinatal Association · 2026Observational
- Association Between Plasma and Urinary Reduced Thiols in Essential Hypertension: Evidence from a Paired Observational Study.Journal of clinical medicine · 2026Article
- Time-dependent relationship between urinary biomarkers of nucleic acid oxidation and colorectal cancer risk.Journal of the National Cancer Institute · 2026Article
- Recreational physical activity and biomarkers of breast cancer risk in a cohort of adolescent girls.Breast cancer research : BCR · 2026Article
- Exercise-induced oxidative and hematological responses in adolescent female swimmers during the luteal phase.Frontiers in physiology · 2026Article
- Oxidative Stress, Metabolic Impairment and Neuroinflammation are Associated With Target Organ Damage in SHRSP.Physiological research · 2025Article
- Effect of GLP-1 RA and SGLT2I on Biomarkers of Oxidative Stress in T2DM: A Systematic Review and Meta-analysis.Journal of the Endocrine Society · 2025Review
- Assessment of blood and urine total antioxidant and oxidative status in alcohol and acetone fatal poisonings.Scientific reports · 2025Article
- Article
- Observational
67 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Oxidative damage produced by reactive oxygen species (ROS) has been implicated in the etiology and pathology of many health conditions, including a large number of chronic diseases. Urinary biomarkers of oxidative status present a great opportunity to study redox balance in human populations. With urinary biomarkers, specimen collection is non-invasive and the organic/metal content is low, which minimizes the artifactual formation of oxidative damage to molecules in specimens. Also, urinary levels of the biomarkers present intergraded indices of redox balance over a longer period of time compared to blood levels. This review summarizes the criteria for evaluation of biomarkers applicable to epidemiological studies and evaluation of several classes of biomarkers that are formed non-enzymatically: oxidative damage to lipids, proteins, DNA, and allantoin, an oxidative product of uric acid. The review considers formation, metabolism, and exertion of each biomarker, available data on validation in animal and clinical models of oxidative stress, analytical approaches, and their intra- and inter-individual variation. The recommended biomarkers for monitoring oxidative status over time are F₂-isoprostanes and 8-oxodG. For inter-individual comparisons, F₂-isoprostanes are recommended, whereas urinary 8-oxodG levels may be confounded by differences in the DNA repair capacity. Promising urinary biomarkers include allantoin, acrolein-lysine, and dityrosine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.