SynthesisHeart rhythm2012
A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.
Synthesis in Heart rhythm, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern.JCI insight · 2019Pooled it
- Early repolarization in adolescent athletes: A gender comparison of ECG and echocardiographic characteristics.Scandinavian journal of medicine & science in sports · 2022Article
- Dietary vitamin D intake and colorectal cancer risk: a longitudinal approach within the PREDIMED study.European journal of nutrition · 2021Article
- Genome-wide association studies of cardiac electrical phenotypes.Cardiovascular research · 2020Review
- Epidemiology of inherited arrhythmias.Nature reviews. Cardiology · 2020Review
- Electrophysiological Basis for Early Repolarization Syndrome.Frontiers in cardiovascular medicine · 2018Review
- Early repolarization syndrome caused byHeartRhythm case reports · 2017Article
- Epidemiology in Germany-general development and personal experience.European journal of epidemiology · 2017Article
- Heart Disease and Stroke Statistics-2017 Update: A Report From the American Heart Association.Circulation · 2017Review
- Twenty-eight genetic loci associated with ST-T-wave amplitudes of the electrocardiogram.Human molecular genetics · 2016Article
- Increased prevalence of early repolarization in electrocardiograms of psoriatic patients.Heart and vessels · 2016Article
- Early Repolarisation Syndrome - New Concepts.Arrhythmia & electrophysiology review · 2015Article
- Early repolarization pattern: its ECG characteristics, arrhythmogeneity and heritability.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2014Review
- Heart disease and stroke statistics--2014 update: a report from the American Heart Association.Circulation · 2014Article
Corrections and comments
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Authors and funding
44 authors.
Funding
Abstract
backgroundThe early repolarization pattern (ERP) is common and associated with risk of sudden cardiac death. ERP is heritable, and mutations have been described in syndromatic cases.
objectiveTo conduct a meta-analysis of genome-wide association studies to identify common genetic variants influencing ERP.
methodsWe ascertained ERP on the basis of electrocardiograms in 3 large community-based cohorts from Europe and the United States: the Framingham Heart Study, the Health 2000 Study, and the KORA F4 Study. We analyzed genome-wide association studies in participants with and without ERP by logistic regression assuming an additive genetic model and meta-analyzed individual cohort results. We then sought to strengthen support for findings that reached P ≤ 1 × 10(-5) in independent individuals by direct genotyping or in-silico analysis of genome-wide data. We meta-analyzed the results from both stages.
resultsOf 7482 individuals in the discovery stage, 452 showed ERP (ERP positive: mean age 46.9 ± 8.9 years, 30.3% women; ERP negative: 47.5 ± 9.4 years, 54.2% women). After meta-analysis, 8 single nucleotide polymorphisms reached P ≤ 1 × 10(-5): The most significant finding was intergenic rs11653989 (odds ratio 0.47; 95% confidence interval 0.36-0.61; P = 6.9 × 10(-9)). The most biologically relevant finding was intronic to KCND3: rs17029069 (odds ratio 1.46; 95% confidence interval 1.25-1.69; P = 8.5 × 10(-7)). In the replication step (7151 individuals), none of the 8 variants replicated, and combined meta-analysis results failed to reach genome-wide significance.
conclusionsIn a genome-wide association study, we were not able to reliably identify genetic variants predisposing to ERP, presumably due to insufficient statistical power and phenotype heterogeneity. The reported heritability of ERP warrants continued investigation in larger well-phenotyped populations.
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