Evidence map›Paper›PMID 22683423›Full record

ReviewTranslational research : the journal of laboratory and clinical medicine2012

Emerging view of the human virome.

Kristine M Wylie, George M Weinstock, Gregory A Storch

Abstract readReview
In one paragraph

Review in Translational research : the journal of laboratory and clinical medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Saliva assay: a call for methodological standardization.Journal of periodontal & implant science · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Revolutionized virome research using systems microbiology approaches.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
  19. Article
  20. Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kristine M WylieThe Genome Insititute, Washington University School of Medicine, St Louis, MO, USA.
George M Weinstock
Gregory A Storch

Funding

Sequencing the Human MicrobiomeU54HG004968 · NHGRI · WASHINGTON UNIVERSITY · PI WEINSTOCK, GEORGE M · 2009 to 2012
$16.7M
DEFINING THE HUMAN VIROME IN IMMUNOCOMPROMISED CHILDRENR01AI097213 · NIAID · WASHINGTON UNIVERSITY · PI STORCH, GREGORY A. · 2012 to 2016
$3.2M
THE HUMAN VIROME IN CHILDREN AND ITS RELATIONSHIP TO FEBRILE ILLNESSUH2AI083266 · NIAID · WASHINGTON UNIVERSITY · PI STORCH, GREGORY A. · 2009 to 2010
$1.4M
NHGRI NIH HHS U54 HG004968NIAID NIH HHS R01 AI097213NIAID NIH HHS UH2 AI083266
6 · The paper itself

Abstract

The human virome is the collection of all viruses that are found in or on humans, including both eukaryotic and prokaryotic viruses. Eukaryotic viruses clearly have important effects on human health, ranging from mild, self-limited acute or chronic infections to those with serious or fatal consequences. Prokaryotic viruses can also influence human health by affecting bacterial community structure and function. Therefore, definition of the virome is an important step toward understanding how microbes affect human health and disease. We review progress in virome analysis, which has been driven by advances in high-throughput, deep sequencing technology. Highlights from these studies include the association of viruses with clinical phenotypes and description of novel viruses that may be important pathogens. Together these studies indicate that analysis of the human virome is critical as we aim to understand how microbial communities influence human health and disease. Descriptions of the human virome will stimulate future work to understand how the virome affects long-term human health, immunity, and response to coinfections. Analysis of the virome ultimately may affect the treatment of patients with a variety of clinical syndromes.

Indexed as

HumansRNA, Ribosomal, 16SRNA, ViralVirus DiseasesVirusesRNA, Ribosomal, 16SRNA, Viral

Identifiers

PMID22683423
PMCPMC3701101

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.