ArticleEnvironmental research2012
Organophosphate pesticide levels in blood and urine of women and newborns living in an agricultural community.
Article in Environmental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 143 citations in OpenAlex.
- Systematic Literature Review of the Take-Home Route of Pesticide Exposure via Biomonitoring and Environmental Monitoring.International journal of environmental research and public health · 2019Pooled it
- Neurodevelopmental effects in children associated with exposure to organophosphate pesticides: a systematic review.Neurotoxicology · 2013Pooled it
- Pesticide Exposure Estimation across Census Tracts in Washington State: Identifying Vulnerable Areas and Populations.Environmental health perspectives · 2026Article
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- Colorimetric methods using gold nanoparticles for forensic investigations.Forensic science, medicine, and pathology · 2025Review
- Specific Hepatorenal Toxicity and Cross-Species Susceptibility of Eight Representative Pesticides.Toxics · 2025Article
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- Chlorpyrifos Acts as a Positive Modulator and an Agonist ofJournal of xenobiotics · 2025Article
- The effect of fiber intake on the association of pesticide exposure and hypertension: a population-level study.Frontiers in public health · 2025Article
- Current-use pesticide exposures in remote Inuit communities.International journal of circumpolar health · 2024Article
- Organophosphate pesticide exposure and risk of SARS-CoV-2 infection.Environmental research · 2024Article
- Navigating the Neurological Abyss: A Comprehensive Review of Organophosphate Poisoning Complications.Cureus · 2024Review
- Distribution Characteristics and Risk Assessment of 57 Pesticides in Farmland Soil and the Surrounding Water.Toxics · 2024Article
- Follicular DNA Damage and Pesticide Exposure Among Latinx Children in Rural and Urban Communities.Exposure and health · 2024Article
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- Article
- Article
- The association between organophosphate insecticides and blood pressure dysregulation: NHANES 2013-2014.Environmental health : a global access science source · 2022Article
- Impact of High-Throughput Model Parameterization and Data Uncertainty on Thyroid-Based Toxicological Estimates for Pesticide Chemicals.Environmental science & technology · 2022Article
- Concurrent urinary organophosphate metabolites and acetylcholinesterase activity in Ecuadorian adolescents.Environmental research · 2022Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Organophosphate pesticides are widely used and recent studies suggest associations of in utero exposures with adverse birth outcomes and neurodevelopment. Few studies have characterized organophosphate pesticides in human plasma or established how these levels correlate to urinary measurements. We measured organophosphate pesticide metabolites in maternal urine and chlorpyrifos and diazinon in maternal and cord plasma of subjects living in an agricultural area to compare levels in two different biological matrices. We also determined paraoxonase 1 (PON1) genotypes (PON1(192) and PON1(-108)) and PON1 substrate-specific activities in mothers and their newborns to examine whether PON1 may affect organophosphate pesticide measurements in blood and urine. Chlorpyrifos levels in plasma ranged from 0-1,726 ng/mL and non-zero levels were measured in 70.5% and 87.5% of maternal and cord samples, respectively. Diazinon levels were lower (0-0.5 ng/mL); non-zero levels were found in 33.3% of maternal plasma and 47.3% of cord plasma. Significant associations between organophosphate pesticide levels in blood and metabolite levels in urine were limited to models adjusting for PON1 levels. Increased maternal PON1 levels were associated with decreased odds of chlorpyrifos and diazinon detection (odds ratio(OR): 0.56 and 0.75, respectively). Blood organophosphate pesticide levels of study participants were similar in mothers and newborns and slightly higher than those reported in other populations. However, compared to their mothers, newborns have much lower quantities of the detoxifying PON1 enzyme suggesting that infants may be especially vulnerable to organophosphate pesticide exposures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.