Evidence map›Paper›PMID 22683128›Full record

ReviewLancet (London, England)2012

Prediabetes: a high-risk state for diabetes development.

Adam G Tabák, Christian Herder, Wolfgang Rathmann, Eric J Brunner, Mika Kivimäki

7 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lancet (London, England), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 1,480 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,480citing papers in PubMed, 11 pooled it
58.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02450500 nacompletednot on this mapstarted 2015, after this paper: background citation

Prohealth@Home: A Feasibility Study Investigating the Application of a Web Based Lifestyle App to Improve Glycaemic Control by Changing Dietary and Activity Behaviours in Individuals at High Risk of Type 2 Diabetes

TypeinterventionalSponsorUniversity of PlymouthRan2015 to 2016Enrolled10ConditionsPre-diabetesArmsLifestyle counselling
NCT03294915 naunknown statusnot on this mapstarted 2018, after this paper: background citation

Effect of Resistant Starch From Green Banana Flour on the Insulin Sensitivity of Subjects With Prediabetes: Randomized Clinical Trial

TypeinterventionalSponsorHospital de Clinicas de Porto AlegreRan2018 to 2020Enrolled20ConditionsPrediabetesArmsResistant Starch, Placebo
NCT05640869 naunknown statusnot on this mapstarted 2023, after this paper: background citation

The Diabetes Prevention Program to Treat Overweight and Obesity

TypeinterventionalSponsorAuburn UniversityRan2023 to 2023Enrolled50ConditionsWeight Loss, PreDiabetesArmsModified Diabetes Prevention Program Curriculum
NCT05864183 unknown statusnot on this mapstarted 2023, after this paper: background citation

Screening for Risk Factors of Prediabetes Among Adults Patients at Sohag University Hospital

Typeobservational_patient_registrySponsorSohag UniversityRan2023 to 2023Enrolled200ConditionsPreDiabetesArmsHbA1c, lipid profile, CBC, Alb/cr ratio, serum creatinine .
NCT06067139 narecruitingnot on this mapstarted 2023, after this paper: background citation

Sleep for Health: A Randomized Clinical Trial Examining the Effects of Cognitive Behavioral Therapy for Insomnia on Diabetes Risk

TypeinterventionalSponsorKaiser PermanenteRan2023 to 2027Enrolled300ConditionsDiabetes Mellitus, Type 2, Prediabetic State, Sleep Initiation and Maintenance DisordersArmsSHUTi, Patient Education
NCT06195566 completednot on this mapstarted 2024, after this paper: background citation

Physics Informed Machine Learning-based Prediction and Reversion of Impaired Fasting Glucose Management

TypeobservationalSponsorJelizaveta SokolovskaRan2024 to 2025Enrolled77ConditionsPrediabetic State, Body Weight, Overweight or Obesity, Life Style, Healthy
NCT06518798 nacompletednot on this mapstarted 2024, after this paper: background citation

Pilot Study on Fasting-Mimicking Diet in Asian Americans With Prediabetes

TypeinterventionalSponsorUniversity of California, IrvineRan2024 to 2025Enrolled30ConditionsPrediabetes, Prediabetic StateArmsFasting Mimicking Diet
3 · Its place in the literature

Who cites it

1,480 citing papers in PubMed, 11 syntheses or guidelines pooled it, 2,879 citations in OpenAlex.

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1,420 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Adam G TabákDepartment of Epidemiology and Public Health, University College London, London, UK. a.tabak@ucl.ac.uk
Christian Herder
Wolfgang Rathmann
Eric J Brunner
Mika Kivimäki
Deutsches Diabetes-Zentrum e.V. · DEUniversity College London · GBSemmelweis University · HU

Funding

Socioeconomic gradient in CHD in early old ageR01HL036310 · NHLBI · UNIVERSITY OF LONDON · PI KIVIMAKI, MIKA J, MARMOT, MICHAEL G · 1986 to 2012
$3.1M
Health behaviors over the adult lifecourse and cognitive agingR01AG034454 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2009 to 2013
$1.5M
British Heart Foundation RG/07/008/23674Medical Research Council G0100222Medical Research Council G0902037Medical Research Council G19/35Medical Research Council G8802774NHLBI NIH HHS R01 HL036310NHLBI NIH HHS R01HL036310NIA NIH HHS R01 AG034454NIA NIH HHS R01AG034454
6 · The paper itself

Abstract

Prediabetes (intermediate hyperglycaemia) is a high-risk state for diabetes that is defined by glycaemic variables that are higher than normal, but lower than diabetes thresholds. 5-10% of people per year with prediabetes will progress to diabetes, with the same proportion converting back to normoglycaemia. Prevalence of prediabetes is increasing worldwide and experts have projected that more than 470 million people will have prediabetes by 2030. Prediabetes is associated with the simultaneous presence of insulin resistance and β-cell dysfunction-abnormalities that start before glucose changes are detectable. Observational evidence shows associations between prediabetes and early forms of nephropathy, chronic kidney disease, small fibre neuropathy, diabetic retinopathy, and increased risk of macrovascular disease. Multifactorial risk scores using non-invasive measures and blood-based metabolic traits, in addition to glycaemic values, could optimise estimation of diabetes risk. For prediabetic individuals, lifestyle modification is the cornerstone of diabetes prevention, with evidence of a 40-70% relative-risk reduction. Accumulating data also show potential benefits from pharmacotherapy.

Indexed as

AdultBlood GlucoseDiabetes ComplicationsDisease ProgressionGlobal HealthGlycated HemoglobinHumansHyperglycemiaHypoglycemic AgentsLife StyleMicrocirculationPrediabetic StateRisk Reduction BehaviorBlood GlucoseGlycated HemoglobinHypoglycemic Agents

Identifiers

PMID22683128
PMCPMC3891203
OpenAlexW2107797783

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.