Evidence map›Paper›PMID 22682977›Full record

ReviewCurrent opinion in microbiology2012

Diverse virus-host interactions influence RNA-based regulation during γ-herpesvirus infection.

Lisa M Kronstad, Britt A Glaunsinger

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lisa M KronstadDepartment of Plant and Microbial Biology, 585B Li Ka Shing Center, University of California, Berkeley, CA 94720-3370, USA.
Britt A Glaunsinger
University of California, Berkeley · US

Funding

Disruption of Cellular RNA Processing by Kaposi's Sarcoma-Associated HerpesvirusR01CA136367 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI Britt A Glaunsinger · 2010 to 2026
$5.8M
Escape from gammaherpesvirus-induced mRNA destructionR01CA160556 · NCI · UNIVERSITY OF CALIFORNIA BERKELEY · PI GLAUNSINGER, BRITT A · 2011 to 2015
$1.5M
NCI NIH HHS R01 CA136367NCI NIH HHS R01CA136367NCI NIH HHS R01 CA160556NCI NIH HHS R01CA160556Wellcome Trust
6 · The paper itself

Abstract

Post-transcriptional, RNA-based regulation is a major contributor to alterations in gene expression, and γ-herpesviruses interface with the host RNA targeting machinery in a variety of ways. Several of these interactions involve coordination with cellular ribonucleases, for example to direct non-canonical processing of viral microRNAs or widespread degradation of cellular messenger RNAs. Conversely, select viral transcripts use both cis-acting and trans-acting mechanisms to evade degradation. The diversity of mechanisms used by these viruses to both engage and escape the cellular RNA decay machinery underscores the influence these pathways exert on cellular and viral gene expression. Further research in this field should help reveal new mechanisms of RNA-based regulation in both infected and uninfected cells.

Indexed as

RNA StabilityAnimalsGammaherpesvirinaeGene Expression Regulation, ViralHerpesviridae InfectionsHost-Pathogen InteractionsHumansMicroRNAsRibonucleasesRNA, MessengerRNA, UntranslatedRNA, ViralVirus LatencyMicroRNAsRibonucleasesRNA, MessengerRNA, UntranslatedRNA, Viral

Identifiers

PMID22682977
PMCPMC3424297
OpenAlexW2080436467

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.