ReviewTransfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine2012
Stored red blood cell transfusions: Iron, inflammation, immunity, and infection.
Review in Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06840756 (Effects of Donor-recipient Sex-matched Versus Sex-mismatched Red Blood Cell Transfusion on Outcomes in Critically Ill Adult Patients), which is not on this map. Cited by 45 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Donor-recipient Sex-matched Versus Sex-mismatched Red Blood Cell Transfusion on Outcomes in Critically Ill Adult Patients
Who cites it
45 citing papers in PubMed, 102 citations in OpenAlex.
- Prolonged red cell storage before transfusion increases extravascular hemolysis.The Journal of clinical investigation · 2017Trial
- Liberal versus restrictive blood transfusion strategy: 3-year survival and cause of death results from the FOCUS randomised controlled trial.Lancet (London, England) · 2015Trial
- Association Between Blood Transfusion and Survival Outcomes in Metastatic Cutaneous Melanoma Treated with Nivolumab.Cancer management and research · 2026Article
- Molecular Mechanisms of Transfusion-Associated Immunomodulation and Its Impact in the Critically Ill.International journal of molecular sciences · 2025Review
- Article
- Stored RBC transfusions leads to the systemic inflammatory response syndrome in anemic murine neonates.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Association Between Congenital Heart Disease and Stroke: Insights from a National Database.Pediatric cardiology · 2024Article
- Risk Assessment of Red Cell Transfusion in Congenital Heart Disease.The Thoracic and cardiovascular surgeon · 2022Article
- Detection and follow-up of a soluble alpha-haemoglobin pool in the red cells of stored blood units.Blood transfusion = Trasfusione del sangue · 2022Article
- Inflammatory profile of convalescent plasma to treat COVID: Impact of amotosalen/UVA pathogen reduction technology.Frontiers in immunology · 2022Article
- Transfusion of Anaerobically or Conventionally Stored Blood After Hemorrhagic Shock.Shock (Augusta, Ga.) · 2020Article
- Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle.Circulation research · 2020Review
- Red blood cell storage lesion: causes and potential clinical consequences.Blood transfusion = Trasfusione del sangue · 2019Review
- Characterization of Storage-Induced Red Blood Cell Hemolysis Using Raman Spectroscopy.Laboratory medicine · 2018Article
- NLRP3 Inflammasome Activation Regulates Aged RBC Clearance.Inflammation · 2018Article
- The age of stored erythrocytes influences methaemoglobin formation when circulated in a heart-lung machine model.Blood transfusion = Trasfusione del sangue · 2018Article
- Characteristics of Extracellular Vesicles in Red Blood Concentrates Change with Storage Time and Blood Manufacturing Method.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2018Article
- Mechanisms of red blood cell transfusion-related immunomodulation.Transfusion · 2018Review
- Survey of heavy metals in internal tissues of Great cormorant collected from southern wetlands of Caspian Sea, Iran.Environmental monitoring and assessment · 2017Article
- Effect of red blood cell storage time on markers of hemolysis and inflammation in transfused very low birth weight infants.Pediatric research · 2017Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The potential adverse effects of transfusion of red blood cells after prolonged storage have been hotly debated. During refrigerated storage, red blood cells are damaged, a process known as the red blood cell "storage lesion." We hypothesized that the delivery of a bolus of iron derived from these rapidly cleared, damaged, red blood cells is responsible for some of the adverse effects of transfusion. Iron may play a role in producing a pro-inflammatory response to transfused red blood cells, potentially through the effects of reactive oxygen species on stress pathways and inflammasome activation. Furthermore, the excess iron may impair the host's ability to combat infection by its innate iron-withholding pathways. This symposium paper summarizes the background for the "iron hypothesis" as it relates to transfusion of red blood cells after prolonged refrigerated storage. It also includes a summary of the data from recent murine and human studies, and concludes with a discussion of several unresolved questions arising from these published studies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.