Evidence map›Paper›PMID 22682503›Full record

ArticleGenes, brain, and behavior2012

Additive effects of the dopamine D2 receptor and dopamine transporter genes on the error-related negativity in young children.

A Meyer, D N Klein, D C Torpey, A J Kujawa, E P Hayden, H I Sheikh, S M Singh, G Hajcak

Open access · hybridAbstract read
In one paragraph

Article in Genes, brain, and behavior, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Are We Getting High Cause the Thrill is Gone?Journal of addiction psychiatry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

A MeyerDepartment of Psychology, Stony Brook University, Stony Brook, NY, USA. ammeyer3@gmail.com
D N Klein
D C Torpey
A J Kujawa
E P Hayden
H I Sheikh
S M Singh
G Hajcak
Stony Brook University · US

Funding

Temperamental Low PE in Preschoolers and Depression RiskR01MH069942 · NIMH · STATE UNIVERSITY NEW YORK STONY BROOK · PI KLEIN, DANIEL N · 2004 to 2023
$14.2M
NIMH NIH HHS R01 MH069942
6 · The paper itself

Abstract

The error-related negativity (ERN) is a negative deflection in the event-related potential that occurs approximately 50 ms following the commission of an error at fronto-central electrode sites. Previous models suggest dopamine plays a role in the generation of the ERN. We recorded event-related potentials (ERPs) while 279 children aged 5-7 years completed a simple Go/No-Go task; the ERN was examined in relation to the dopamine D2 receptor (DRD2) and dopamine transporter (DAT1) genes. Results suggest an additive effect of the DRD2 and DAT1 genotype on ERN magnitude such that children with at least one DRD2 A1 allele and children with at least one DAT1 9 allele have an increased (i.e. more negative) ERN. These results provide further support for the involvement of dopamine in the generation of the ERN.

Indexed as

AllelesChildChild BehaviorChild, PreschoolDopamineDopamine Plasma Membrane Transport ProteinsEvoked PotentialsFemaleGenotypeHumansMalePolymorphism, GeneticPsychomotor PerformanceReaction TimeReceptors, Dopamine D2Sex FactorsDopamineDopamine Plasma Membrane Transport ProteinsReceptors, Dopamine D2SLC6A3 protein, human

Identifiers

PMID22682503
PMCPMC3974650
OpenAlexW2135604847

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.