Evidence map›Paper›PMID 22682276›Full record

Trial reportTrials2012

A cost-effectiveness analysis of provider and community interventions to improve the treatment of uncomplicated malaria in Nigeria: study protocol for a randomized controlled trial.

Virginia Wiseman, Ezeoke Ogochukwu, Nwala Emmanuel, Mangham Lindsay J, Cundill Bonnie, Enemuo Jane, Uchegbu Eloka, Uzochukwu Benjamin, Onwujekwe Obinna

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Trials, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01350752 (A Cost-effectiveness Analysis of Alternative Strategies for the Deployment of ACTs at the Community Level in Cameroon and Nigeria), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01350752 nacompletednot on this map

A Cost-effectiveness Analysis of Alternative Strategies for the Deployment of ACTs at the Community Level in Cameroon and Nigeria

TypeinterventionalSponsorLondon School of Hygiene and Tropical MedicineRan2011 to 2015Enrolled6,513ConditionsMalariaArmsRDTs & Provider Training on Malaria Diagnosis and Treatment, Extended provider training (Cameroon only), School based malaria education (Nigeria only)
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Virginia WisemanDepartment of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK. virginia.wiseman@lshtm.ac.uk
Ezeoke Ogochukwu
Nwala Emmanuel
Mangham Lindsay J
Cundill Bonnie
Enemuo Jane
Uchegbu Eloka
Uzochukwu Benjamin
Onwujekwe Obinna

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is mounting evidence of poor adherence by health service personnel to clinical guidelines for malaria following a symptomatic diagnosis. In response to this, the World Health Organization (WHO) recommends that in all settings clinical suspicion of malaria should be confirmed by parasitological diagnosis using microscopy or Rapid Diagnostic Test (RDT). The Government of Nigeria plans to introduce RDTs in public health facilities over the coming year. In this context, we will evaluate the effectiveness and cost-effectiveness of two interventions designed to support the roll-out of RDTs and improve the rational use of ACTs. It is feared that without supporting interventions, non-adherence will remain a serious impediment to implementing malaria treatment guidelines. METHODS/

designA three-arm stratified cluster randomized trial is used to compare the effectiveness and cost-effectiveness of: (1) provider malaria training intervention versus expected standard practice in malaria diagnosis and treatment; (2) provider malaria training intervention plus school-based intervention versus expected standard practice; and (3) the combined provider plus school-based intervention versus provider intervention alone. RDTs will be introduced in all arms of the trial. The primary outcome is the proportion of patients attending facilities that report a fever or suspected malaria and receive treatment according to malaria guidelines. This will be measured by surveying patients (or caregivers) as they exit primary health centers, pharmacies, and patent medicine dealers. Cost-effectiveness will be presented in terms of the primary outcome and a range of secondary outcomes, including changes in provider and community knowledge. Costs will be estimated from both a societal and provider perspective using standard economic evaluation methodologies.

trial registrationClinicaltrials.gov NCT01350752.

Indexed as

Health Care CostsResearch DesignAntimalarialsAttitude of Health PersonnelCommunity Health ServicesCost-Benefit AnalysisCost SavingsDiagnostic Tests, RoutineDrug CostsDrug Therapy, CombinationGuideline AdherenceHealth PersonnelHumansInservice TrainingMalariaNigeriaAntimalarialsReagent Kits, Diagnostic

Identifiers

PMID22682276
PMCPMC3517748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.