ArticleCell metabolism2012
REV-ERBs: more than the sum of the individual parts.
Article in Cell metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Discovery of circadian clock activators with anti-obesity efficacy via suppression of adipocyte development and hypertrophy.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- Quercetin and Fisetin activate circadian clock via RORα and inhibit adipocyte growth.bioRxiv : the preprint server for biology · 2026Article
- Novel circadian clock activators display anti-obesity efficacy via suppression of adipocyte development and hypertrophy.bioRxiv : the preprint server for biology · 2026Article
- Functional Characterization of Circadian Nuclear Receptors REV-ERBα and REV-ERBβ in Human Osteosarcoma Cell Cultures.International journal of molecular sciences · 2024Article
- Targeted screening and identification of chlorhexidine as a pro-myogenic circadian clock activator.Stem cell research & therapy · 2023Article
- The Circadian Regulation of Nutrient Metabolism in Diet-Induced Obesity and Metabolic Disease.Nutrients · 2022Review
- Synergies of Multiple Zeitgebers Tune Entrainment.Frontiers in network physiology · 2021Article
- Weak coupling between intracellular feedback loops explains dissociation of clock gene dynamics.PLoS computational biology · 2019Article
- The Nuclear Receptor and Clock Repressor Rev-erbα Suppresses Myogenesis.Scientific reports · 2019Article
- Co-existing feedback loops generate tissue-specific circadian rhythms.Life science alliance · 2018Article
- Regulation of Clock Genes by Adrenergic Receptor Signaling in Osteoblasts.Neurochemical research · 2018Review
- Feedback Loops of the Mammalian Circadian Clock Constitute Repressilator.PLoS computational biology · 2016Article
- Novel Function of Rev-erbα in Promoting Brown Adipogenesis.Scientific reports · 2015Article
- Nuclear receptors rock around the clock.EMBO reports · 2014Review
- REV-ERB ALPHA polymorphism is associated with obesity in the Spanish obese male population.PloS one · 2014Article
- Metabolic compensation of the Neurospora clock by a glucose-dependent feedback of the circadian repressor CSP1 on the core oscillator.Genes & development · 2012Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
REV-ERB nuclear receptors have been believed to stabilize the circadian clock machinery through an accessory but dispensable feedback loop. Recent work now challenges this assumption by demonstrating that REV-ERBs are essential core clock components, in addition to serving as pivotal regulators of rhythmic metabolism.
Identifiers
22682217What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.