ArticleBMC public health2012
A longitudinal cohort based association study between uric acid level and metabolic syndrome in Chinese Han urban male population.
Article in BMC public health, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Association of Serum Uric Acid Levels in Psoriasis: A Systematic Review and Meta-Analysis.Medicine · 2016Pooled it
- Dose-response Relationship of Serum Uric Acid with Metabolic Syndrome and Non-alcoholic Fatty Liver Disease Incidence: A Meta-analysis of Prospective Studies.Scientific reports · 2015Pooled it
- Fetuin-A Concentration in the Perinatal Period and Maternal BMI Dynamics During Pregnancy, Labor, and Early Postpartum: Is ΔBMI a Parameter Worth Considering?Journal of clinical medicine · 2025Article
- Circulating Bone morphogenetic protein 9 (BMP9) as a new biomarker for noninvasive stratification of nonalcoholic fatty liver disease and metabolic syndrome.Clinical and experimental medicine · 2024Article
- Association between serum uric acid levels and bone mineral density in patients with osteoporosis: a cross-sectional study.BMC musculoskeletal disorders · 2023Article
- Correlation Analysis between Uric Acid and Metabolic Syndrome in the Chinese Elderly Population: A Cross-Sectional Study.International journal of endocrinology · 2023Article
- The Impact of Maternal Prenatal Stress Related to the COVID-19 Pandemic during the First 1000 Days: A Historical Perspective.International journal of environmental research and public health · 2022Review
- The visceral and liver fat are significantly associated with the prevalence of hyperuricemia among middle age and elderly people: A cross-sectional study in Chongqing, China.Frontiers in nutrition · 2022Article
- The Association Between Spicy Food Intake and Risk of Hyperuricemia Among Chinese Adults.Frontiers in public health · 2022Article
- Uric acid as a predictor of endothelial dysfunction in patients with metabolic syndrome.Archives of endocrinology and metabolism · 2021Article
- Association between baseline and changes in serum uric acid and incident metabolic syndrome: a nation-wide cohort study and updated meta-analysis.Nutrition & metabolism · 2021Article
- Metabolic Syndrome-Related Hyperuricemia is Associated with a Poorer Prognosis in Patients with Colorectal Cancer: A Multicenter Retrospective Study.Cancer management and research · 2021Article
- Association of Serum Uric Acid with cardio-metabolic risk factors and metabolic syndrome in seafarers working on tankers.BMC public health · 2020Article
- Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Mendelian Randomization Analysis.BioMed research international · 2020Observational
- Macronutrient intake and physical activity levels in individuals with and without metabolic syndrome: An observational study in an urban population.ARYA atherosclerosis · 2019Article
- Visceral adiposity index is strongly associated with hyperuricemia independently of metabolic health and obesity phenotypes.Scientific reports · 2017Article
- The Associations of Serum Uric Acid with Obesity-RelatedInternational journal of endocrinology · 2017Article
- Asymptomatic hyperuricemia is not an independent risk factor for cardiovascular events or overall mortality in the general population of the Busselton Health Study.BMC cardiovascular disorders · 2016Article
- Evaluation of Association of Hyperuricaemia with Metabolic Syndrome and Insulin Resistance.Journal of clinical and diagnostic research : JCDR · 2016Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt has been recently demonstrated that serum uric acid (UA) is associated with metabolic syndrome (MetS) or its related clinical indications based on cross-sectional or prospective cohort studies. Nonetheless, due to the fact that UA level constantly fluctuates from time to time even for the person, using a single measure of UA level at baseline of those studies may not be sufficient for estimating the UA-Mets association.
methodsTo further estimate this time-dependent association, we fitted a generalized estimating equation (GEE) regression model with data from a large-scale 6-year longitudinal study, which included 2222 participants aged > =25 years with an average of 3.5 repeated measures of UA per person in the Health Management Center of Shandong Provincial Hospital, Shandong, China.
resultsAfter adjusting for other potential confounding factors (i.e., total cholesterol, low-density lipoprotein), it was verified that time-dependent UA level was an independent risk factor for MetS (OR = 1.6920, p < 0.0001). It was found that UA level was positively associated with obesity, hypertension, and dyslipidemia, but was inversely associated with hyperglycemia.
conclusionsSerum UA level may serve as an important risk factor of MetS. Additionally, our study suggested that UA level be an independent risk factor to obesity, hypertension and dyslipidemia, but a protective factor to hyperglycemia. These findings are concordant with results from other studies on Asian populations, and jointly provide a basis to further develop a risk assessment model for predicting MetS using UA levels and other factors in China.
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