SynthesisClinical nutrition (Edinburgh, Scotland)2012
Fish consumption, omega-3 fatty acids and risk of heart failure: a meta-analysis.
Synthesis in Clinical nutrition (Edinburgh, Scotland), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 6 syntheses or guidelines pooled it, 167 citations in OpenAlex.
- The Optimal Dosage and Duration of ω-3 PUFA Supplementation in Heart Failure Management: Evidence from a Network Meta-Analysis.Advances in nutrition (Bethesda, Md.) · 2025Pooled it
- α-Linolenic Acid and Risk of Heart Failure: A Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Relationship Between Dietary Omega-3 and Omega-6 Polyunsaturated Fatty Acids Level and Sarcopenia. A Meta-Analysis of Observational Studies.Frontiers in nutrition · 2021Pooled it
- Fish Consumption and the Risk of Chronic Disease: An Umbrella Review of Meta-Analyses of Prospective Cohort Studies.Advances in nutrition (Bethesda, Md.) · 2020Pooled it
- Association between intake of red and processed meat and the risk of heart failure: a meta-analysis.BMC public health · 2019Pooled it
- Omega-3 fatty acid supplementation as an adjunctive therapy in the treatment of chronic kidney disease: a meta-analysis.Clinics (Sao Paulo, Brazil) · 2017Pooled it
- Omega 3 fatty acids effect on the vascular calcification biomarkers fetuin A and osteoprotegerin in hemodialysis patients.Clinical and experimental medicine · 2022Trial
- TMAO, creatine and 1-methylhistidine in serum and urine are potential biomarkers of cod and salmon intake: a randomised clinical trial in adults with overweight or obesity.European journal of nutrition · 2020Trial
- Plasma and dietary omega-3 fatty acids, fish intake, and heart failure risk in the Physicians' Health Study.The American journal of clinical nutrition · 2012Trial
- In Vivo Assessment of Human Intramyocellular Fatty Acid Composition Using 7 T.NMR in biomedicine · 2026Article
- Polygenic predisposition modifies the associations of fish oil supplementation with circulating omega-3 fatty acids: a cross-sectional gene-diet interaction study in UK Biobank.medRxiv : the preprint server for health sciences · 2026Article
- Dietary fatty acids and epigenetic aging in US adults: results from the National Health and Nutrition Examination Survey.npj aging · 2025Article
- Bioaccumulation and Biomagnification of Mercury Along the Seafood Chain in Europe: A Systematic Review.Foods (Basel, Switzerland) · 2025Review
- Bioactive Compounds in Seafood: Implications for Health and Nutrition.Food science & nutrition · 2025Review
- Article
- Omega-3 fatty acids in the treatment of heart failure.Current problems in cardiology · 2024Review
- Marine omega-3 fatty acid supplementation and prevention of cardiovascular disease: update on the randomized trial evidence.Cardiovascular research · 2023Review
- Fish consumption in multiple health outcomes: an umbrella review of meta-analyses of observational and clinical studies.Annals of translational medicine · 2023Article
- Trends in dietary intake and food sources of long-chain polyunsaturated fatty acids among Korean adults between 2007 and 2018.Epidemiology and health · 2023Article
- Fish Consumption and Risk of Stroke in Chinese Adults: A Prospective Cohort Study in Shanghai, China.Nutrients · 2022Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND &
aimsWhile marine omega-3 fatty acids have been associated with a lower mortality in heart failure patients, data on omega-3 and incident heart failure are inconsistent. We systematically reviewed the evidence on the association of omega-3 fatty acids and fish intake with the incidence of heart failure in this meta-analysis.
methodsWe identified relevant studies by searching MEDLINE and EMBASE databases up to August 31, 2011 without restrictions and by reviewing reference lists from retrieved articles.
resultsA total of 176,441 subjects and 5480 incident cases of heart failure from 7 prospective studies were included in this analysis. Using random effect model, the pooled relative risk for heart failure comparing the highest to lowest category of fish intake was 0.85 (95% CI; 0.73-0.99), p = 0.04; corresponding value for marine omega-3 fatty acids was 0.86 (0.74-1.00), p = 0.05. There was no evidence for heterogeneity across studies of fish consumption (I(2) = 8%). In contrast, there was modest heterogeneity for omega-3 fatty acid analysis (I(2) = 44%). Lastly, there was no evidence for publication bias.
conclusionsThis meta-analysis is consistent with a lower risk of heart failure with intake of marine omega-3 fatty acids. These observational findings should be confirmed in a large randomized trial.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.