ReviewFertility and sterility2012
The next (re)generation of ovarian biology and fertility in women: is current science tomorrow's practice?
Review in Fertility and sterility, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- Integration of Bioengineered Tools in Assisted Reproductive Technologies.Advanced healthcare materials · 2025Review
- Extracellular vesicles in stem cell-based gonadal regeneration: mechanisms, therapeutic potential, and translational challenges.Frontiers in veterinary science · 2025Review
- Innovative Strategies for Fertility Preservation in Female Cancer Survivors: New Hope from Artificial Ovary Construction and Stem Cell-Derived Neo-Folliculogenesis.Healthcare (Basel, Switzerland) · 2023Review
- Characterization of the In Vitro Cultured Ovarian Cells in the Asian Yellow Pond Turtle (Biology · 2022Article
- The making of 'old eggs': the science of reproductive ageing between fertility and anti-ageing technologies.Reproductive biomedicine & society online · 2022Article
- Role of Stem Cells in the Ovarian Tissue Cryopreservation and Transplantation for Fertility Preservation.International journal of molecular sciences · 2021Review
- Human Adipose-Derived Stem Cells' Paracrine Factors in Conditioned Medium Can Enhance Porcine Oocyte Maturation and Subsequent Embryo Development.International journal of molecular sciences · 2021Article
- Research Progress on the Treatment of Premature Ovarian Failure Using Mesenchymal Stem Cells: A Literature Review.Frontiers in cell and developmental biology · 2021Review
- Article
- Review
- Generation of Artificial Gamete and Embryo From Stem Cells in Reproductive Medicine.Frontiers in bioengineering and biotechnology · 2020Review
- New Frontiers in IVF: mtDNA and autologous germline mitochondrial energy transfer.Reproductive biology and endocrinology : RB&E · 2019Review
- Extracellular matrix signaling activates differentiation of adult ovary-derived oogonial stem cells in a species-specific manner.Fertility and sterility · 2019Article
- Review
- Female Fertility Preservation through Stem Cell-based Ovarian Tissue Reconstitution In Vitro and Ovarian Regeneration In Vivo.Clinical medicine insights. Reproductive health · 2019Review
- Genetic studies in mice directly link oocytes produced during adulthood to ovarian function and natural fertility.Scientific reports · 2017Article
- Tracing and Characterizing the Development of Transplanted Female Germline Stem Cells In Vivo.Molecular therapy : the journal of the American Society of Gene Therapy · 2017Article
- Used protocols for isolation and propagation of ovarian stem cells, different cells with different traits.Journal of ovarian research · 2016Review
- Autologous Germline Mitochondrial Energy Transfer (AUGMENT) in Human Assisted Reproduction.Seminars in reproductive medicine · 2015Review
- Perspective in infertility: the ovarian stem cells.Journal of ovarian research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Stem cell-based strategies for ovarian regeneration and oocyte production have been proposed as future clinical therapies for treating infertility in women. However, utilization of embryonic stem cells or induced pluripotent stem cells to produce oocytes has had limited success in vitro. A recent report of the isolation and characterization of endogenous oocyte-producing or oogonial stem cells (OSCs) from ovaries of reproductive age women describes the first stable and pure human female germ cell culture model in which a subset of cells appear to initiate and complete meiosis. In addition, purified human OSCs introduced into adult human ovarian cortical tissue generate oocytes that arrest at the diplotene stage of meiosis and successfully recruit granulosa cells to form new primordial follicles. This overview examines the current landscape of in vitro and in vivo gametogenesis from stem cells, with emphasis on generation of human oocytes. Future research objectives for this area of work, as well as potential clinical applications involving the use of human OSCs, are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.